鹦鹉热衣原体肺炎病例报告2例及文献复习

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Abstract Two patients had a history of pigeon contact and presented with fever, fatigue and dyspnea. One patient developed acute respiratory distress syndrome (ARDS) on the fourth day of the disease and required non-invasive ventilator assisted ventilation. Leukocyte count was slightly increased in 2 patients, lymphocyte percentage was decreased, platelet count was normal, procalcitonin was increased, C-reactive protein was significantly increased, alanine aminotransferase and aspartate aminotransferase were increased to varying degrees, serum sodium, potassium and albumin were decreased, erythrocyte sedimentation rate (ESR) was normal in 1 patient and slightly increased in 1 patient. The pathogen could not be identified by routine culture and serological examination of blood and alveolar lavage fluid. Chest X-ray, computed tomography (CT) showed large exudation and consolidation of one lung lobe, rapid progression in severe cases, involving both lung lobes, respiratory failure, and poor effect of empirical antibiotic use. After timely application of metagenomic next-generation sequencing (mNGS) technology combined with avian contact history, the patient was finally diagnosed with Chlamydia psittaci pneumonia. After treatment with quinolones combined with tetracycline antibiotics, the symptoms, signs and imaging abnormalities of the patient were significantly improved, but 1 patient had poor imaging absorption and was further treated with macrolide antibiotics for 1 week. Follow-up examination of chest CT showed that the lesion was basically absorbed. By analyzing the clinical characteristics, diagnosis and treatment process of these two patients, it can provide reference for clinical diagnosis and treatment of these diseases.

Key words： Severe pneumonia Chlamydia psittaci Metagenomic next-generation sequencing Hepatic damage

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	LI Heqiang1 PENG Xiu1 WANG Xiaohong2

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LI Heqiang1 PENG Xiu1 WANG Xiaohong2. Two cases of Chlamydia psittaci pneumonia and literature review[J]. 中国当代医药, 2024, 31(1): 140-145.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2024/V31/I1/140

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