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| Clinical significance of food-specific IgG antibodies in common chronic diseases in children |
| HU Yongzhong CHEN Xuemei |
| Department of Laboratory, Xinyu Maternal and Child Health Hospital, Jiangxi Province, Xinyu 338025, China |
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Abstract Objective To analyze the role of food-specific immunoglobulin G (IgG) antibody detection in common chronic diseases in children. Methods From January to December 2021, 200 children who were treated in the Department of Dermatology, Child Health Care, Traditional Chinese Medicine and Pediatrics of Xinyu Maternal and Child Health Hospital were selected as the study objects, and 200 healthy people were selected during the same period as the healthy control group. Serum IgG antibodies of 14 kinds of food were detected in the subjects, and the detection results were analyzed. Results Food-specific IgG was detected in 172 cases, the total positive rate was 86.00% (172/200). The positive rate of specific IgG in milk, egg and wheat was the highest. In addition, all other foods except cod caused the increase of IgG concentration, mainly mild sensitive cases, moderate sensitive cases and high sensitive cases. The proportion of male and female children was 50.50% and 49.50%, respectively. The top 3 IgG positive percentages were milk, egg and wheat, and the IgG positive percentage of male children shrimp was higher than that of female children, the difference was statistically significant (P＜0.05). There was no significant difference between genders in beef, chicken and other foods (P＞0.05). Among 172 specific IgG positive patients, digestive system and skin system diseases accounted for the most positive patients, 90.63% and 92.39%, respectively. The serum specific IgG antibody concentrations of 14 foods in the children group were higher than those in the healthy control group, the differences were statistically significant (P＜0.05). Conclusion Food-specific IgG antibody detection has high value in common chronic diseases in children, and provides new ideas for the treatment of some chronic diseases.
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