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| Clinical significance of N-terminal pro-B-type natriuretic peptide and hypersensitive C-reactive protein in predicting immunoglobulin A nephropathy with cardiac insufficiency |
| DAI Jianfeng LI Li HOU Jin YU Li |
| Research Laboratory of Kidney Disease, Jiujiang Traditional Chinese Medicine Hospital, Jiangxi Province, Jiujiang 332000, China |
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Abstract Objective To explore the clinical significance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and hypersensitive C-reactive protein (hs-CRP) in the predicting of immunoglobulin A nephropathy (IgAN) with cardiac insufficiency. Methods A total of 60 patients with IgAN admitted to Jiujiang Traditional Chinese Medicine Hospital from January to December 2022 were selected as the study subjects, and 60 normal examinees during the same period were selected as the control group. By measuring creatinine levels in patients, glomerular filtration rate (GFR) in IgAN patients was calcuiated, the staging of IgAN related chronic kidney disease (CKD) in patients was evaluated, and cardiac ultrasound examinations on all patients was conducted, the level of cardiac dysfunction was determined based on left ventricular ejection fraction (LVEF) and clinical manifestations. According to the level of cardiac dysfunction, patients were divided into group A (n=20), group B (n=17), group C (n=13), and group D (n=10), the differences in serum NT-proBNP and hs-CRP levels among five groups were detected and compared, and Spearman correlation analysis was used to examine the relationship between NT-proBNP, hs-CRP, CKD stage, LVEF, and level of cardiac dysfunction. Results The GFR levels among four groups was compared, the difference was statistically significant (P＜0.05) between group D＜group C＜group B＜group A; the CKD staging of the four groups was compared, and the staging of groups C and D was higher than that of groups A and B, the differences were statistically significant (P＜0.05); the LVEF levels of 5 groups were compared, the difference were statistically significant (P＜0.05) between group D＜group C＜group B＜group A＜control group; The levels of NT-proBNP and hs CRP in 5 groups were compared, with group D＞group C＞group B＞group A＞control group, and the differences were statistically significant (P＜0.05). Spearman correlation analysis showed that the serum NT-proBNP and hs-CRP levels in IgAN patients were significantly positively correlated with CKD stage and heart failure grade, and significantly negatively correlated with LVEF (P＜0.05). Conclusion NT-proBNP and hs-CRP can both serve as predictive indicators for patients with IgAN complicated with heart failure, and NT-proBNP and hs-CRP can reflect CKD staging and level of heart failure. Early detection and analysis have important clinical significance for preliminary diagnosis and treatment policy formulation.
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