加减黄芪健脾汤治疗脾胃虚弱型慢性结肠炎反复发作性腹泻的临床研究

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (623 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical effect of modified Huangqi Jianpi Decoction in treating recurrent diarrhea in chronic colitis of dual deficient of spleen and stomach type. Methods A total of 60 cases of patients with chronic colitis admitted to the Department of Traditional Chinese Medicine (TCM) Internal Medicine of Dalian Central Hospital from December 2020 to August 2022 were selected as subjects. The patients were divided into the treatment group and the control group by random number table method, with 30 cases in each group. The treatment group was given modified Huangqi Jianpi Decoction. The control group was treated with Live Combined Bacillus Subtilis and Enterococcus Faecium Enteric-coated Capsules. The levels of T-lymphocyte subpopulations (CD3+ and CD4+) and TCM symptom scores were recorded before treatment and 2, 4, 8 weeks after treatment. The clinical efficacy and recurrence rate after one month of drug cessation in the two groups were compared. Results The levels of blood T-lymphocyte subpopulations (CD3+ and CD4+) in the treatment group were higher than those in the control group at 2, 4 and 8 weeks after treatment, and the differences were statistically significant (P＜0.05). The total clinical symptom scores of patients in the treatment group were lower than those of the control group at 2, 4 and 8 weeks after treatment, and the differences were statistically significant (P＜0.05). The total effective rate of treatment in the treatment group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The recurrence rate of patients in the treatment group was lower than that of the control group at one month of drug cessation, and the difference was statistically significant (P＜0.05). Conclusion Modified Huangqi Jianpi Decoction in the treatment of recurrent diarrhea of dual deficiency of spleen and stomach type of chronic colitis obtains a significant effect. It can improve the clinical symptoms of the patients, and enhance their immune function.

Key words： Modified Huangqi Jianpi Decoction Dual deficiency of spleen and stomach type Recurrent diarrhea Clinical study

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XIE Zehong HE Fenghua▲ LIU Yuzi WU Ye LIANG Lijie LI Shu CHEN Yonghe HONG Anjing

Cite this article:

XIE Zehong HE Fenghua▲ LIU Yuzi WU Ye LIANG Lijie LI Shu CHEN Yonghe HONG Anjing. Clinical study of modified Huangqi Jianpi Decoction in treating recurrent diarrhea in chronic colitis of dual deficient of spleen and stomach type[J]. 中国当代医药, 2024, 31(1): 98-102.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2024/V31/I1/98

[1]	段文强.真武汤合六君子汤加减治疗脾肾阳虚型慢性结肠炎60例临床观察[J].中国实用医药，2017，12（2）：140-141.
[2]	葛君，李亚俊，刘爱琴，等，慢性溃疡性结肠炎小鼠的肠黏膜屏障受损的研究[J]中华医学杂志，2018，98（48）：3950-3953.
[3]	傅晓丹，吴丹，付善云.中药滴注灌肠与参苓白术散内服治疗溃疡性结肠炎疗效对比初探[J].贵州医药，2016，40（8）：856-857.
[4]	王蕊.温阳止泻汤治疗脾肾阳虚溃疡型结肠炎36例[J].中医研究杂志，2004，23（4）：44.
[5]	梁桂美，麦绮红，赵桂先，等.玉屏风颗粒联合柳氮磺吡啶治疗慢性结肠炎的效果[J].中国当代医药，2015，22（6）：157-159.
[6]	朱颖玲，唐晓华，吴红铃.中西医结合疗法治疗溃疡性结肠炎的疗效及对凝血功能、炎性因子水平的影响分析[J].中国医药科学，2016，6（23）：82-86.
[7]	苏炳伟，苏建军.慢性腹泻的中西医治疗临床疗效比较[J].内蒙古中医药，2012，31（2）：33-34.
[8]	樊春华，吕永慧.关于慢性结肠炎诊断标准的拟定与诊治探讨[C].//2006中华中医药学会脾胃病分会第十八次学术交流会，2006：336-340.
[9]	中华医学会消化病学分会炎症性肠病协作组.对我国炎症性肠病诊断治疗规范的共识意见[J].现代消化及介入诊疗，2008，13（2）：139-145.
[10]	郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002.
[11]	Saez A，Herrero-Fernandez B，Gomez-Bris R，et al.Pathophysiology of inflammatory bowel disease：Innate immune system[J].Int J Mol Sci，2023，24（2）：1526.
[12]	Liu F，Lee SA，Riordan SM，et al.Effects of anti-cytokine antibodies on gut barrier function[J].Med Inflammation，2019， 2019：1-15.
[13]	王占云.补中益气汤治疗慢性结肠炎120例疗效观察[J].当代医学，2010，16（12）：153.
[14]	唐永祥，王华.寒.温并用方药调治慢性胃肠病机理探析[J].中国中医基础医学杂志，2020，26（8）：1157-1159.
[15]	首汉蓉，唐建，黄泽林，等黄芩汤加减联合补脾益肠丸对溃疡性结肠炎患者Toll样受体4/髓样分化因子88信号通路的影响[J]陕西中医，2020，41（6）：750-753.
[16]	徐国良，周殿元，潘令嘉，等.慢性结肠炎的病因学研究[J].临床消化病杂志，1992，4（3）：99.
[17]	Mukhopadhya I，Hansen R，El-Omar EM，et al.IBD-what role do Proteobacteria play?[J].Nat Rev Gastroenterol Hepatol，2012，9（4）：219-230.
[18]	Mawdsley JE，Rampton DS.Psychological stress in IBD：new insights into Pathogenic and therapeutic implications[J].Gut，2005，54（10）：1481-1491.
[19]	Alsoud D，Verstockt B，Fiocchi C，et al.Breaking the therapeutic ceiling in drug development in ulcerative colitis[J].Lancet Gastroenterol Hepatol，2021，6（7）：589-595.
[20]	甄建华，黄光瑞.溃疡性结肠炎中医病名、病因、病机的古今比较和回顾[J].环球中医药，2019，12（8）：1286-1289.