Abstract Objective To investigate the related factors of neovascular glaucoma (NVG) after pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR). Methods The clinical data of 65 PDR patients who underwent PPV in Nanchang Bright Eye Hospital from January 2021 to January 2023 were retrospectively analyzed. According to whether NVG occurred after surgery, they were divided into the occurrence group (n=18) and the non-occurrence group (n=47). The general data of the patients were collected, including gender, age, body mass index, duration of diabetes, PDR stage, insulin injection, cardiovascular and cerebrovascular diseases, preoperative intraocular pressure, fasting blood glucose, anemia, retinal detachment, combined cataract surgery, preoperative anterior chamber angle or iris neovascularization. The general data were analyzed by univariate analysis, and then the factors with statistically significant differences were analyzed by multivariate logistic regression analysis. Results Among the 65 PDR patients treated with PPV, 18 cases of NVG occurred, with an incidence of 27.69%. Univariate analysis showed that there were no significant differences in body mass index, duration of diabetes, PDR stage, insulin injection, preoperative intraocular pressure, retinal detachment, and combined cataract surgery between the two groups (P＞0.05). There were statistically significant differences between the two groups in gender, age, whether complicated with cardiovascular and cerebrovascular diseases, fasting blood glucose, anemia, and whether there were anterior chamber angle or iris neovascularization (P＜0.05). Multivariate logistic regression analysis showed that male gender (β=1.567, P=0.024, OR=4.792, 95%CI: 1.224-18.766), age＜60 years (β=2.380, P=0.003, OR=10.800, 95%CI: 2.225-52.413), cardiovascular and cerebrovascular diseases (β=1.707, P=0.003, OR=5.814, 95%CI: 1.791-18.870), fasting blood glucose ≥7.0 mmol/L (β=1.655, P=0.006, OR=5.231, 95%CI: 1.623-16.853), anemia (β=1.892, P=0.002, OR=6.635, 95%CI: 2.010-21.900), preoperative or iris neovascularization corner of the eye (β=1.905, P=0.004, OR= 6.720, 95%CI: 1.808-24.981) were the independent risk factors (P＜0.05 and OR＞1). Conclusion There are many influencing factors for NVG after PPV in PDR patients, including male gender, age＜60 years old, combined with cardiovascular and cerebrovascular diseases, fasting blood glucose≥7.0 mmol/L, etc. Clinical attention should be paid to relevant conditions and prevention work should be done.
LONG Kailin WANG Chen ZHAO Kerui DAI Hansheng. Influencing factors of neovascular glaucoma in patients with proliferative diabetic retinopathy after pars plana vitrectomy[J]. 中国当代医药, 2024, 31(1): 27-30.
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