快速启动高效抗反转录病毒治疗对较高CD4+T淋巴细胞的人类免疫缺陷病毒感染-艾滋病患者治疗依从性及预后的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (549 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of rapid initiation of highly active antiretroviral therapy (HAART) on the treatment compliance and prognosis of human immunodeficiency virus infected acquired immune deficiecy syndrome (HIVAIDS) patients with high CD4+T lymphocytes. Methods From July to December 2021, 61 HIVAIDS patients hospitalized in Department of Infectious Diseases, Jiangxi Xinyu People's Hospital were selected. 32 patients who went to the hospital in time within 7 days after diagnosis and started antiviral treatment with informed consent were set as the fast start group. 29 patients who did not go to the AIDS clinic in time after diagnosis or did not receive the fast start HAART after transfer were set as the fast start group. The baseline viral load (HIV-RNA) and CD4+T lymphocyte count of two groups of patients, as well as the viral load and CD4+T lymphocyte count were recorded after 6 and 12 months of antiviral treatment, and the treatment compliance, virus inhibition rate, and follow-up loss rate of the enrolled patients were recorded. Results The the CD4+T lymphocyte count in the rapid start group was higher than that in the non rapid start group at 6 and 12 months of treatment, with statistically significant difference (P＜0.05). After 6 and 12 months of treatment, the HIV-RNA level of the two group was lower than before treatment, while the HIV-RNA level in the rapid start group was lower than those in the non rapid start group at 6 and 12 months of treatment, with astatistically significant difference (P＜0.05). The treatment compliance of the rapid start group was 100.00% (32/32), and the virus inhibition rate was 93.75% (30/32), which were higher than 82.76% (24/29) and 68.97% (20/29) of the non rapid start group, the differences were statistically significant (P＜0.05). The loss of follow-up rate was 0, which was lower than 17.24% (5/29) of the non rapid start group, the difference was statistically significant (P＜0.05). Conclusion Rapid initiation (within 7 days of diagnosis) of HAART can maximize the adherence of HIV/AIDS patients with high CD4+T lymphocytes to antiviral treatment, increase the virus inhibition rate, CD4+T lymphocyte count level, and reduce the loss of follow-up rate, which is worthy of clinical promotion.

Key words： Human immunodeficiency virus infection Acquired Immune Deficiecy Syndrome Quickly initiate efficient antiretroviral therapy Virus load Compliance Prognosis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Min KUANG Lingzhi LIU Min

Cite this article:

ZHOU Min KUANG Lingzhi LIU Min. Effect of rapid initiation of highly active antiretroviral therapy on treatment compliance and prognosis of human immunodeficiency virus infected acquired immune deficiecy syndrome patients with high CD4+T lymphocytes[J]. 中国当代医药, 2024, 31(1): 23-26.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2024/V31/I1/23

[1]	李文婷.信息-动机-行为延续护理模式对艾滋病患者院外自护能力的影响[J].中国医药科学，2021，11（23）：131-134.
[2]	张波.2012—2021年南宁市取消互助献血后无偿献血者HIV阳性分布情况分析[J].中国医药科学，2023，13（8）：136-140.
[3]	刘尹正泽，肖寒，梁欣，等.外周血淋巴细胞计数在艾滋病患者HAART治疗中的变化及其对疗效的影响[J].中国医药科学，2021，11（11）：20-23.
[4]	Mcintosh EC，Tureson K，Rotblatt LJ，et al.HIV，Vascμlar Risk Factors，and Cognition in the Combination Antiretroviral Therapy Era：A Systematic Review and Meta-Analysis[J].J Int Neuropsychol Soc，2021，27（4）：365-381.
[5]	黄郁媚，沈智勇，陆华湘，等.广西地区老年HIV/AIDS病例高效抗逆转录病毒治疗疗效及药物不良反应的分析[J].华南预防医学，2021，47（5）：635-637，641.
[6]	卫生部传染病标准专业委员会.艾滋病和艾滋病病毒感染诊断标准[J].中国艾滋病性病，2012，18（4）：272-275.
[7]	杨婷婷，童叶青，殷晓旭，等.Morisky服药依从性量表、家庭APGAR问卷在结核病患者中的应用评价[J].中国社会医学杂志，2016，33（6）：580-582.
[8]	薛明，李晶晶，闫铄，等.艾滋病并发结核相关免疫重建炎性反应综合征的胸部CT影像表现及与CD4+T淋巴细胞水平的相关性[J].临床放射学杂志，2021，40（3）：80-484.
[9]	孟珺，聂晓勇，原琛利，等.2014-2019年山西省艾滋病免费抗病毒治疗的免疫学效果分析[J].预防医学情报杂志，2022，38（7）：921-926.
[10]	郭琪，臧希卉，孙柳燕，等.2014年—2018年吉林省新报告HIV/AIDS病例首次CD4+T淋巴细胞检测情况分析[J].中国卫生检验杂志，2020，30（21）：2617-2621.
[11]	俞海亮，杨跃诚，赵燕，等.德宏傣族景颇族自治州成年人HIV/AIDS抗病毒治疗后CD4^（+）T淋巴细胞免疫重建及影响因素分析[J].中华流行病学杂志，2021，42（6）：1050-1055.
[12]	杜波，马玉霞，田晓东，等.阜新市高效抗反转录病毒治疗的HIV/AIDS病人基因型耐药情况及影响因素[J].中国艾滋病性病，2020，26（8）：814-818.
[13]	辅海平.桐乡市艾滋病患者接受HAART后生存状况调查研究[J].中国预防医学杂志，2020，21（11）：1161-1165.
[14]	马宁，康续，赵砚，等.CD4^（+）/CD8^（+）比值在HIV感染者/AIDS患者抗逆转录病毒治疗效果评估中的应用研究[J].国际病毒学杂志，2021，28（2）：145-148.
[15]	梁丽娟，陈荣凤，蒋俊俊，等.使用LPV/r+3TC方案治疗的广西初治HIV/AIDS患者的基本特征，短期治疗效果和更换治疗方案的影响因素[J].广西医学，2022，44（9）：964-969.
[16]	马玉霞，刘宁，杜波，等.辽宁省阜新市2011-2019年HIV/AIDS抗病毒治疗免疫学失败分析[J].中国热带医学，2021，21（7）：648-653.
[17]	吴虹，陈珺芳，许珂.杭州市2011—2018年HIV/AIDS抗病毒治疗患者基线CD4+T细胞变化趋势及晚治疗情况分析[J].国际流行病学传染病学杂志，2021，48（3）：197- 201.
[18]	范晓梅，陈雪枫，魏宝楚，等.高效抗反转录病毒治疗HIV感染后心电图异常与CD4+T淋巴细胞计数的关联性研究[J].兰州大学学报：医学版，2021，47（4）：64-68.
[19]	张兰，王洪州，邓丽娟，等.绵阳地区HIV/AIDS抗病毒治疗依从性及生活质量现状调查研究[J].安徽医药，2022， 26（7）：1340-1346.
[20]	罗超，颜玉涛，杨璧璘，等.哈尔滨市社会组织开展男男同性传播艾滋病病毒感染者/艾滋病患者病例随访效果分析[J].中国当代医药，2022，29（35）：156-159.
[21]	程丽，胡健女，杨小红，等.应用智能电子药盒对HIV感染孕妇孕期HAART服药依从性的影响[J].中国艾滋病性病，2020，26（2）：148-150，154.