Objective To investigate the effect of Bufei Huoxue Capsules combined with Umeclidinium Bromide and Vilanterol Trifenatate on stable chronic obstructive pulmonary disease (COPD).Methods Sixty patients with stable COPD admitted to the outpatient department of Jiangxi Chest Hospital from June 2021 to November 2022 were selected as the study objects,and were divided into control group (30 cases) and study group (30 cases) according to random number table method.The control group was treated with Umeclidinium Bromide and Vilanterol Trifenatate,while the study group was treated with Bufei Huoxue Capsules combined with Umeclidinium Bromide and Vilanterol Trifenatate.Lung function,exercise tolerance,quality of life and acute exacerbation of symptoms were compared between the two groups after continuous treatment for 3 months.Results Before treatment,there were no statistical significances in total lung volume(TLC),forced expiratory volume at 1 second(FEV1),forced vital capacity(FVC)and one-second rate(FEV1%)between two groups (P＞0.05).After treatment,the levels of FEV1,FVC and FEV1% in the study group were higher than those in the control group,and the level of TLC was lower than that in the control group,the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in 6-minute walking distance (6MWT),St.George's breathing questionnaire(SGRQ),COPD self-assessment questionnaire(CAT)between control group and study group(P＞0.05).After treatment,the 6MWT of the study group was longer than that of the control group,but the SGRQ score and CAT score were lower than those of the control group,the differences were statistically significant (P＜0.05).The acute aggravation times of cough,expectoration,chest tightness and asthma in the study group were less than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion For stable COPD patients,the treatment of Bufei Huoxue Capsules combined with Umeclidinium Bromide and Vilanterol Trifenatate can significantly improve the symptoms of patients,reduce the number of acute exacerbations,improve lung function,quality of life,improve the exercise ability of patients,and can be widely used.