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| Clinical study of endoscopic gastroesophageal valve ligation for refractory reflux esophagitis |
| YI Jian GUI Guan ZHANG Shanjin WU Yuwen FAN Huizhen |
| Department of Gastroenterology,Yichun People's Hospital,Jiangxi Province,Yichun 336000,China |
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Abstract Objective To investigate the efficacy and safety of endoscopic gastroesophageal valve ligation for refractory reflux esophagitis.Methods A total of 44 patients with refractory reflux esophagitis admitted to Yichun People's Hospital from May 2019 to May 2021 were selected as the research objects,and they were divided into the control group (22 cases)and the observation group (22 cases) according to random number table method.The control group was treated with conventional medicine,and the observation group was treated with endoscopic gastroesophageal valve ligation.All patients were followed up for 6 months.The health related quality of life questionnaire for gastroesophageal reflux disease(GERD-HRQL) score,gastroesophageal reflux disease questionnaire (GERDQ) score,esophagitis grading,valve Hill grading,the total satisfaction degree of symptom control,proton pump inhibitor use and the incidence of adverse reactions were compared between the two groups.Results There were no significant differences in the GERD-HRQL score and GERDQ score between the two groups before treatment (P＞0.05).After treatment,the GERD-HRQL score and GERDQ score in the two groups were lower than those before treatment,the differences were statistically significant (P＜0.05).The GERD-HRQL score and GERDQ score of the observation group were lower than those of the control group after treatment,and the differences were statistically significant(P＜0.05).The grade of esophagitis in the observation group was better than that in the control group,and the difference was statistically significant (P＜0.05).The Hill grading of valve disc in the observation group was better than that in the control group,and the difference was statistically significant (P＜0.05).The total satisfaction degree of symptom control in the observation group was higher than that in the control group,the difference was statistically significant (P＜0.05).The usage of proton pump inhibitors in the observation group was better than that in the control group,and the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Endoscopic gastroesophageal valve ligation is effective in the treatment of refractory reflux esophagitis,which can effectively reduce GERD-HRQL score and GERDQ score,improve esophagitis and valve Hill grade,speed up the symptoms of reflux,reduce the impact of the disease on daily life,and it is safe and reliable.
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