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| The clinical study of low dosage of Losartan combined with the Prescription of Strengthening Kidney and Reducing Acid treating the early primary gouty nephropathy |
| LIU Han-wei1 TANG Ji-wen2 ZOU Li-e3 LING Jia-sheng4 |
1.Medical Department,Huizhou Traditional Chinese Medicine Hospital in Guangdong Province,Huizhou 516001,China;
2.Department of Emergency,Huizhou Traditional Chinese Medicine Hospital in Guangdong Province,Huizhou 516001, China;
3.Hemodialysis Center,Huizhou Traditional Chinese Medicine Hospital in Guangdong Province,Huizhou 516001, China;
4.The Second Department of Internal Medicine,Huizhou Traditional Chinese Medicine Hospital in Guangdong Province,Huizhou 516001,China |
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Abstract ObjectiveTo investigate the clinical effect of low dosage of Losartan combined with the Prescription of Strengthening Kidney and Reducing Acid treating the early uric acid nephropathy.MethodsA total of 100 patients with early uric acid nephropathy admitted into our hospital from September 2014 to September 2016 were selected and divided into two groups:control group and observation group with 50 cases in each group according to the principle of randomized controlled classification.Based on the basis of the same treatment,the patients of the control group was treated with Allopurinol and the patients of the observation group was treated with low dosage of Losartan combined with the prescription of Strengthening Kidney and Reducing Acid.After 3 months of continuous treatment,the clinical symptoms improvement,the improvement of clinical indexes and the clinical efficacy between the two groups were compared.ResultsAfter treatmrent,the improvement of clinical symptoms,renal function index and 24 h urine protein quantitative were significantly better than those of the control group after treatment and the difference was statistically significant(P＜0.05).After treatment,the total effective rate of the observation group was significantly higher than that of the control group and the differencewasstatisticallysignificant(P＜0.05).ConclusionLowdosageofLosartancombinedwiththe PrescriptionofStrengtheningKidney and Reducing Acid treating the early uric acid nephropathy can clinical symptoms, renal function,uric acid,24 h urinary protein and other short-effect index,and it can protect renal function,improve the total efficiency rate of clinical treatment,and it is a feasible treatment method.It is worthy of further clinical application and promotion in clinic.
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