Abstract Objective To evaluate the application of training in non-alcoholic fatty liver disease (NAFLD).Methods PubMed,Embase,EBSCO,Cochrane Library,JBI,China National Knowledge Infrastructure,WanFang Database,VIP and Chinese Biomedical Literature Database in recent ten years were searched on the effect of exercise intervention on related indicators in patients with NAFLD.After independent literature screening,data extraction and literature quality evaluation,RevMan 5.3 statistical software was used for meta-analysis of the included data.Results A total of 11 randomized controlled trials (RCT) were included,and the results showed that alanine aminotransferase (ALT)(MD=-5.77,95%CI [-10.53,-1.00],P=0.02),aspartate aminotransferase (AST) (MD=-4.22,95%CI [-7.68,-0.76],P=0.02),low-density lipoprotein cholesterol (LDL-C) (MD=-7.20,95%CI [-13.10,-1.30],P=0.02),visceral adipose tissue(VAT) (MD=-0.51,95%CI [-0.91,-0.11],P=0.01) and subcutaneous adipose tissue (SAT) (MD=-0.54,95%CI [-0.76,-0.33],P＜0.01) of the exercise intervention group were lower than those in conventional treatment group,and the differences were statistically significant (P＜0.05).There were no statistically significant differences in high density lipoprotein cholesterol (HDL-C) (MD=0.02,95%CI [-0.06,0.10],P=0.60),serum total cholesterol (TC) (MD=-0.14,95%CI [-0.75,0.46],P=0.64),triglyceride (TG) (MD=0.04,95%CI [-0.12,0.20],P=0.62) between the two groups (P＞0.05).Conclusion Exercise intervention can be used as the first choice for non-drug treatment of NAFLD patients,which is safe and reliable.
Cuthbertson DJ，Shojaee-Moradie F，Sprung VS，et al.Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease[J].Clin Sci （Lond），2016，130（2）：93-104.
[5]
Zhang HJ，He J，Pan L，et al.Effects of Moderate and Vigorous Exercise on Nonalcoholic Fatty Liver Disease：A Randomized Clinical Trial[J].JAMA Intern Med，2016，176（8）：1074-1082.
[6]
Pugh CJ，Spring VS，Kemp GJ，et al.Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease[J].Am J Physiol Heart Circ Physiol，2014，307（9）：1298-1306.
[7]
Christopher JP，Cuthbertson DJ，Sprung VS，et al.Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease[J].Am J Physiol Endocrinol Metab，2013，305（1）：50-58.
[8]
Sullivan S，Kirk EP，Mittendorfer B，et al.Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease[J].Hepatology，2012，55（6）：1738-1745.
[9]
Rezende RE，Duarte SM，Stefano，JT，et al.Randomized clinical trial：benefits of aerobic physical activity for 24 weeks in postmenopausal women with nonalcoholic fatty liver disease[J].Menopause，2016，23（8）：876-883.
[10]
Hallsworth K，Thoma C，Hollingsworth KG，et al.Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease：a randomized controlled trial[J].Clin Sci （Lond），2015，129（12）：1097-1105.
[11]
Hallsworth K，Fattakhova G，Hollingsworth KG，et al.Resistance ex ercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss[J].Gut，2011，60（9）：1278-1283.
[12]
Zelber-Sagi S，Buch A，Hanny H，et al.Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial[J].World J Gastroenterol，2014，20（15）：4382.
[13]
Shamsoddini A，Sobhani V，Ghamar Chehreh ME，et al.Effect of Aerobic and Resistance Exercise Training on Liver Enzymes and Hepatic Fat in Iranian Men With Nonalcoholic Fatty Liver Disease[J].Hepat Mon，2015，15（10）：314-334.
[14]
Houghton D，Thoma C，Hallsworth K，et al.Exercise Reduces Liver Lipids and Visceral Adiposity in Patients With Nonalcoholic Steatohepatitis in a Randomized Controlled Trial[J].Clin Gastroenterol Hepatol，2017，15（1）：96-102.
