痛风患者治疗效果与心理状况相关性分析

Abstract
Figure/Table
References (19)
Related Citation (15)

Download: PDF (0 KB) HTML (41 KB)
Export: BibTeX | EndNote (RIS) Supporting Info

Guide

Abstract Objective To explore the correlation between the therapeutic effect and psychological status of gout patients，and to provide reference for their clinical treatment and quality of life improvement.Methods From September 2018 to September 2019，200 patients diagnosed as gout in Huizhou Central People′s Hospital were selected as the research objects.After 20 weeks of standardized application of drugs，the therapeutic effect indexes of patients were evaluated before and after treatment，mainly including clinical symptom integral evaluation of gout，fasting blood uric acid level，erythrocyte sedimentation rate，C-reactive protein，ultrasonic image change indexes，monitoring liver and kidney function indexes to evaluate the drug safety and psychological status of patients with gout，and explore the correlation between the therapeutic effect and psychological status.Results There were no significant differences in serum alanine aminotransfease (ALT) and aspartate aminotransferase (AST) between the two groups before and after treatment (P＞0.05).After treatment，the levels of urea nitrogen (BUN)，creatinine，uric acid，synovium thickness，self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were lower than those before treatment (P＜0.05);after treatment，the synovial thickness was lower than that before treatment，and the blood flow signal pannus resistance index (RI) was higher than that before treatment (P＜0.05).SAS and SDS scores were positively correlated with BUN，creatinine，serum uric acid and synovial thickness，and negatively correlated with RI (P＜0.05).Conclusion The clinical symptoms，inflammatory indexes，serum uric acid level，ultrasound imaging results and psychological state of patients treated with Febuxostat combined with celecoxib were significantly improved.

Key words： font-size: 16px Gout;Febuxostat;Therapeutic effect;Ultrasound;Psychological condition')" href="#">text-align: justify;">Gout;Febuxostat;Therapeutic effect;Ultrasound;Psychological condition

PACS:

Fund:

	Service

	E-mail this article Gout;Febuxostat;Therapeutic effect;Ultrasound;Psychological condition”. Please open it by linking:https://www.dangdaiyiyao.com/EN/abstract/abstract13483.shtml" name="neirong">
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Xue-zhen1 CHEN Xiao-ying2 TAN Zhi-ming3 ZHUANG Yu3 TAO Yi1 HUANG Wen-hui1▲

Cite this article:

ZHANG Xue-zhen1 CHEN Xiao-ying2 TAN Zhi-ming3 ZHUANG Yu3 TAO Yi1 HUANG Wen-hui1▲. Analysis of the correlation between the therapeutic effect and psychological status of gout patients[J]. 中国当代医药, 2020, 27(33): 167-170.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I33/167

[1]	Petrie KJ，Mac Krill K，Derksen C，et al.An Illness by any Other name：The effect of renaming gout on illness and Treatment perceptions[J].Health Psychol，2017，37（1）：37-41.
[2]	Zhou Q，Su J，Zhou T.A study comparing the safety and efficacy of febuxostat，allopurinol，and benzbromarone in Chinese gout patients：a retrospective cohort study[J].Int J Clin Pharmacol Ther，2017，55（2）：163-168.
[3]	Pardin T，Richette P.Impact of comorbidities on gout and hyperuricaemia：an update on prevalence and treatment options[J].BMC Med，2017，15（1）：123-131.
[4]	王笑青，张依山，时红磊.自拟痛风方治疗急性痛风性关节炎疗效观察[J].风湿病与关节炎，2017，6（8）：48-50.
[5]	王斌，李向培，宋维亚.痛风患者痛风知识认知调查[J].中华临床免疫和变态反应杂志，2018，12（4）：23-27.
[6]	郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：110-116.
[7]	Szkudlarek M，Court-Payen M，Jacobsen S.Nterobserver agreement in ultrasonogrephy of the finger and toe joints in rheumatioid arthritis[J].Arthritis Rheum，2003，48（4）：955-962
[8]	费雅楠，唐素玫，张舸，等.痛风性关节炎患者关节超声不同表现下骨破坏指标的比较[J].中华医学杂志，2018，98（13）：978-981.
[9]	宋美艳.系统性心理护理对痛风所致抑郁症患者的疗效影响及研究[J]大家健康（学术版），2015，（7）：224-225.
[10]	何俊锋.非布司他与别嘌醇在痛风治疗中降尿酸有效性和安全性比较[J].临床合理用药杂志，2017，10（17）：12-13.
[11]	Cleophas MCl，Joosten LA，Stamp LK，et al.ABCG2 polymorphisms in gout：insights into disease susceptibility and treatment approaches[J].Pharmacogenomics Per Med，2017，10：129-142.
[12]	董倩，朱雪梅，陈玉珍，等.痛风及高尿酸血症患者饮食控制依从性影响因素的研究进展[J].解放军护理杂志，2018，35（15）：39-42，54
[13]	赖志廷.非布司他治疗痛风伴高尿酸血症的安全性及应用效果评估[J].中国医学创新，2018，15（7）：124-126.
[14]	Frampton JE.Febuxostat：A review of its use in the treatment of hyperuricaemia in patients with gout[J].Drugs，2015，75（4）：427.
[15]	贾西.痛风治疗新理念——EULAR2016 痛风诊治指南的更新要点和解读[J].上海医药，2018，39（2）：3-7.
[16]	余俊文.广东省佛山市居民尿酸血症及痛风的流行病学调查[J].中华流行病学杂志，2010，31（8）：860-862
[17]	Choi HK，Curhan G：Beer，liquor，and wine consumption and serumufic acid level：the Third National Health and Nutrition Examination Survey[J].Arthritis Rheum，51（6）：1023-1029，2004
[18]	Shibagaki Y.Safety，efficacy and renal effect of febuxostat in patients with moderate-to-severe kidney dysfuntion[J].Curr Opin Nephrol Hypertens，2014．37（10）：919-925．
[19]	Terslev L.Doppler ultrasound and magnetic resonance imaging of synovial inflammation of the hand in rheumatoid arthritis-A comparative study[J].Arthritis Rheum，2003，48（9）：2434-2441.