缓解期双相情感障碍患者及其近亲属和正常人群认知功能对照研究

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Abstract ObjectiveTo compare the cognitive function between patients with bipolar affective disorder in remission period and its close relatives and normal population.Methods50 cases of bipolar affective disorder typeⅠpatients in remission period in our hospital from January 2015 to June 2016 were selected as the study group 1,50 cases of bipolar affective disorder typeⅡpatients in remission period were selected as the study group 2,50 cases healthy close relatives from two study groups were selected as the relatives group and 50 normal subjects were selected as the control group.All the subjects were assessed respectively by the digit symbol,trail making test A(TMT-A)time,trail making test B (TMT-B)time,digital breadth (forward,backward,total score)and Wisconsin card sorting test (WCST),and the attention,memory and executive function of each group were compared.ResultsThe TMT-A time,TMT-B time and digital breadth (forward)of the study group 1 and the study group 2 were higher than those in the relatives group and the control group,with significant difference (P＜0.05).The TMT-A time and TMT-B time of the study group 1 were longer than those of the study group 2,with significant difference(P＜0.05).The digital breadth(backward)and the total digital breadth score of the study group 1 and the study group 2 were significantly lower than those in the relatives group and the control group,with significant difference(P＜0.05).The number of digital symbols in the control group was significantly higher than that in the other three groups,with significant difference (P＜0.05).The non-persistent error number,error responses of WSCT in the study group 1,thestudy group 2 and the relatives group were significantly higher than that in the control group,with significant difference(P＜0.05).The non-persistent error number,error responses of WSCT in the study group 1 and the relatives group were significantly higher than that in the study group 2,with significant difference (P＜0.05).There was significant difference in the complete classification number,non-maintaining complete classification number and the number of responses required to complete the first classification and the number of total responses between the study group 1,the relatives group and the study group 2,the control group (P＜0.05).ConclusionThere are many cognitive impairment in patients with typeⅠand typeⅡin remission stage and their close relatives,and the damage of executive power in typeⅠpatients is more obvious,the damage of attention in typeⅡpatients is more obvious than that in typeⅠpatients.

Key words： Bipolar affective disorder Close relatives Cognitive function Remission period TypeⅠ TypeⅡ

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	XU De-chun
	ZHANG Cheng-cheng

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XU De-chun,ZHANG Cheng-cheng. Comparative study of cognitive function in patients with bipolar affective disorder in remission period and their close relatives and normal population[J]. 中国当代医药, 2017, 24(18): 41-43转46.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I18/41

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