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| Effect of Dapagliflozin Tablets on blood glucose, insulin resistance and matrix metalloproteinase-2 in diabetic patients |
| ZHENG Chang |
| Department of Pharmacy, Fujian Provincial Hospital, Fujian Province, Fuzhou 350001, China |
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Abstract Objective To investigate the effect of Dapagliflozin Tablets on blood glucose, insulin resistance and matrix metalloproteinase-2 (MMP-2) in diabetic patients. Methods A total of 200 diabetic patients from Fujian Provincial Hospital from October 2020 to October 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 100 patients in each group. The control group was treated with Metformin, and the observation group was treated with Dapagliflozin Tablets. The total effective rate, fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h PG), fasting insulin (FINS), insulin resistance index (HOMA-IR) and MMP-2 contents were compared between the two groups. Results The total effective rate in observation group (90.00%) was higher than that in control group (65.00%), and the difference was significant (P＜0.05). Before treatment, there were no significant differences in FBG, 2 h PG, FINS, HOMA-IR and MMP-2 content between the two groups (P＞0.05). The FBG, 2 h PG, FINS, HOMA-IR and MMP-2 content in the two groups after treatment were lower than those before treatment, and the FBG, 2 h PG, FINS, HOMA-IR and MMP-2 content in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P＜0.05). Con-clusion Dapagliflozin Tablets can effectively reduce blood glucose in diabetic patients, and has a significant effect on improving insulin resistance and inhibiting MMP-2 level.
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