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| Distribution and drug resistance analysis of pathogenic bacteria in infected wounds of diabetic foot patients |
| LYU Fuping ZHANG Manjing |
| Department of Endocrinology and Diabetes, the First Affiliated Hospital of Xiamen University, Fujian Province, Xiamen 350108, China |
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Abstract Objective To investigate the distribution and drug resistance of pathogenic bacteria in infected wounds of patients with diabetic foot (DF). Methods A total of 135 patients with DF with wound infection treated in the First Affiliated Hospital of Xiamen University from May 2017 to April 2019 were selected. The samples of infected wound secretions were collected, and the bacterial culture, isolation and identification and drug sensitivity test were carried out. The distribution and drug resistance of pathogens in the infected wound of DF patients were analyzed. Results A total of 149 strains of pathogens were detected in 135 patients with DF with bacterial infection, including 65 strains of Gram-negative bacteria (GNB), accounting for 43.62% (65/149), 73 strains of Gram-positive bacteria (GPB), accounting for 48.99% (73/149), and 11 strains of fungi, accounting for 7.38% (11/149). The results of drug sensitivity test showed that the top three of GPB sensitivity were Linezolid, Moxifloxacin and Vancomycin respectively, and the top three of drug resistance were Penicillin, Oxacillin and Ampicillin respectively; the top three of GNB sensitivity were Imipenem, Meropenem and Amoxicillin/Clavulanic Acid, and the top three of drug resistance were Amoxicillin, Ticarcillin and Ceftazidime. Conclusion GPB and GNB are the main pathogens of wound secretion of DF with bacterial infection, and different pathogens have different drug resistance. Antibiotics should be selected reasonably in combination with the pathogen situation of DF patients.
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