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| Application of Amlodipine Benazapril Tablets (Ⅱ) in elderly patients with hypertension and coronary heart disease |
| YANG Yanmin1 ZHANG Xia2 BU Xiaojie1 JIA Jingjing1 WANG Hongwei |
1. Department of Health Care, Rizhao People's Hospital, Shandong Province, Rizhao 276800, China;
2. Clinical Laboratory, Central Health Center of Nanhu Town of Donggang District of Rizhao City, Shandong Province, Rizhao 276817, China |
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Abstract Objective To investigate the application of Amlodipine Benazapril Tablets (Ⅱ) in elderly patients with hypertension and coronary heart disease. Methods From April 2020 to April 2021, 92 elderly patients with hypertension and coronary heart disease admitted to Rizhao People's Hospital were selected as the study objects. They were divided into the reference group and the trial group, with 46 cases in each group. Patients in the reference group were treated with Amlodipine Tablets orally, and patients in the trial group were treated with Amlodipine Beenapril Tablets (Ⅱ) orally. The levels of 24 h mean diastolic blood pressure (24 h DBP), 24 h mean systolic blood pressure (24 h SBP), endothelin-1 (ET-1), and nitric oxide (NO) before and after treatment were compared, and the efficacy of the two groups were compared. Results There was no statistical difference in the levels of 24 h DBP, 24 h SBP between the two groups before treatment (P＞0.05). After treatment, the levels of 24 h DBP and 24 h SBP in the two groups were lower than before treatment, the differences were significant (P＜0.05). The levels of 24 h DBP and 24 h SBP in the trial group after treatment were lower than those in the reference group, the differences were significant (P＜0.05). There were no statistical difference in the levels of ET-1 and NO between the two groups before treatment (P＞0.05). The levels of ET-1 in the two groups after treatment were lower than those before treatment, and the levels of NO in the two groups after treatment were higher than those before treatment, the differences were significant (P＜0.05). Thelevel of ET-1 in the trial group was lower than that in the reference group, and the level of NO in the trial group after treatment was higher than that in the reference group, the differences were significant (P＜0.05). The total effective rate in the trial group was higher than that in the reference group, the difference was significant (P＜0.05). Conclusion For elderly patients with hypertension and coronary heart disease, Amlodipine Beenapril Tablets (Ⅱ) can better control blood pressure, improve vascular endothelial function, and improve its therapeutic effect.
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