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| Clinical application value of combined detection of D-dimer, NLR and BNP in the diagnosis and treatment of acute exacerbation of chronic obstructive pulmonary diseas |
| XIAO Shibin1 ZHANG Yufang2 HUANG Changyan1 |
1. Department of Laboratory, Ganzhou Municipal Hospital, Jiangxi Province, Ganzhou 341000, China;
2. Department of Blood Transfusion, Ganzhou Municipal Hospital, Jiangxi Province, Ganzhou 341000, China |
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Abstract Objective To investigate the clinical application value of the combined detection of D-dimer (D-D),neutrophilto lymphocyte ratio (NLR) and B-type natriuretic peptide (BNP) in the diagnosis and treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 160 patients with chronic obstructive pulmonary disease (COPD) in Ganzhou Municipal Hospital from January 2021 to December 2021 were selected as the research objects. According to the conditions, the patients in the acute exacerbation stage were set as the observation group, and the patients in the stable stage were set as the control group. The levels of D-D, NLR and BNP in the two groups were detected and compared, and the Pearson correlation was used to analyze the correlation among D-D, NLR and BNP, and the receiver operating characteristic curve (ROC) was used to analyze the diagnosis of AECOPD by D-D, NLR and BNP value. Results The levels of BNP in the observation group were lower than those in the control group, and the levels of D-D and NLR were higher than those in the control group, the differences were statistically significant (P<0.05). The correlation analysis showed that D-D, NLR and BNP were all negatively correlated(r=-0.803, -0.862, P<0.001). The ROC analysis results showed that the cut-off values of D-D, NLR, BNP and the combined diagnosis of liver cirrhosis were 1.525, 5.740, 200.075 and 0.485 respectively, and the areas under the curve were 0.974, 0.993, 1.000 and 1.000 respectively. The combined diagnosis was higher than the single diagnosis.Conclusion The combined detection of D-D, NLR and BNP has high sensitivity and specificity in the diagnosis and treatment of AECOPD, and has high diagnostic value, which is worthy of clinical promotion.
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