精神分裂症患者神经营养因子血清浓度与临床症状相关性研究

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Abstract ObjectiveTo study the correlation among brain-derived neurotrophic factor(BDNF),nerve gowth factor(NGF) and the clinical manifestation in first episode schizophrenia.MethodsDouble antibody sandwich enzyme-linked immunosorbentassay(ELISA)was adopted to quantitate BDNF and NGF serum levels of 38 first episode schizophrenic patients hospitalized in Department of Early Intervention of our Hospital from September 2015 to November 2016 and 50 healthy people for medical examinations.Positive and negative syndrome scale(PANSS)was used to evaluate the clinical state of the patients.BNDF and NGF serum concentration of the two groups was analyzed.Pearson correlative analysis was adopted to analyze the correlation between BDNF,NGF serum concentrations and PANSS scores in patient group.ResultsNo statistical differences was found in age,gender or years of education in two groups.Lower BDNF serum levels[(2913.19± 638.30)pg/ml]were found(t=4.465,P＜0.01)in the patient group than in healthy subjects[(355.3±685.98)pg/ml].Lower NGF serum concentrations[(36.96±8.28)pg/ml]were found(t=3.450，P＜0.01)in the patient group than in the controls[(44.30± 10.94)pg/ml].BDNF serum concentrations and PANSS scores were not correlated in patient group.There were no correlations found among,PANSS-positive scores,PANSS-general scores and PANSS-Total scores in the patient group,however, NGF serum levels were negatively related to PANSS-negtive scores in patient group(r=-0.256,P＜0.05).BDNF was found positively related to NGF serum levels(r=0.378,P＜0.01).ConclusionCognitive impairments occurred in schizophrenic patients,and NGF in the serum may impact growth and development of nervous system.BDNF and NGF may play similar role on nosogenesis of schizophrenia.

Key words： Schizophrenia BDNF NGF

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	Articles by authors
	WAN Jing
	HUANG Cai-ying
	XUE Kun-xi
	HU Jing
	PING Jun-jiao
	DU Bao-guo

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WAN Jing,HUANG Cai-ying,XUE Kun-xi, et al. Research on serum correlation of neurotrophin and clinical symptoms in first episode Schizophrenia[J]. 中国当代医药, 2017, 24(19): 50-52.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I19/50

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