Objective To explore the effect of oxygen-driven atomization inhalation on the prevention and treatment of radioactive oral mucosal reaction in patients with laryngeal cancer.Methods A total of 101 patients with laryngeal cancer who underwent radiotherapy in Ganzhou Tumor Hospital from February 2017 to July 2019 were selected.They were divided into the observation group (51 cases) and the control group (50 cases) according to the method of random digital table.Both groups were given routine oral nursing.Meanwhile,the control group received ultrasonic atomization inhalation therapy,and the observation group received oxygen-driven atomization inhalation therapy.The saliva flow,oral pH value at the time of before treatment,radiotherapy dose 33 Gy,the end of radiotherapy and the end of radiotherapy for 1 week and the occurrence of radioactive oral mucosal reaction at the time of radiotherapy dose 33Gy,the end of radiotherapy and the end of radiotherapy for 1 week were compared between the two groups.Results The oral pH value of the observation group at the time of radiotherapy dose 33 Gy,the end of radiotherapy and the end of radiotherapy for 1 week were higher than those of the control group,and the differences were statistically significant (P＜0.05).The saliva flow of the observation group at the time of radiotherapy dose 33 Gy,the end of radiotherapy and the end of radiotherapy for 1 week were greater than those of the control group,and the differences were statistically significant (P＜0.05).The radioactive oral mucosal reaction of the observation group at the time of radiotherapy dose 33 Gy,the end of radiotherapy and the end of radiotherapy for 1 week were better than those of the control group,the differences were statistically significant (P＜0.05).Conclusion Oxygen-driven atomization inhalation can effectively prevent radioactive oral mucosal reaction in patients with laryngeal cancer.