Objective To investigate the application effect of Misoprostol in premature rupture of fetal membrane at term.Methods From June 2018 to September 2019,a total of 100 cases of premature rupture of membranes to full term pregnant women treated in our hospital were selected as the research objects.According to the random number table,they were divided into observation group and control group,each with 50 cases.The control group accetped Oxytocin,observation group accetped Misoprostol,maternal labor,hormone levels before and after medication,maternal and infant outcomes,adverse drug reactions and other indicators of the two groups were compared.Results The first,second and third stages of labor in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The serum progesterone (P) of the two groups of pregnant women 6 h after treatment was lower than that before treatment,while the serum prostaglandin E (PGE) and serum estrogen (E2) levels were higher than those before treatment,and the serum P of the observation group 6 h after treatment was lower than that of the control group,serum PGE,E2 were higher than those of the control group,the differences were statistically significant(P＜0.05).The cesarean section rate in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).There were no statistically significant differences in the rate of postpartum hemorrhage,neonatal asphyxia,and fetal distress between the two groups (P＞0.05).There were no statistically significant differences in the adverse reactions between the two groups of parturients during the medication period(P＞0.05).Conclusion Misoprostol has important application value in the induction of labor with full-term premature rupture of membranes.It can quickly help mothers improve hormone levels,improve maternal and infant outcomes,and has high drug safety.