血栓弹力图在妊娠期糖尿病孕妇凝血功能检测中的应用价值

Abstract
Figure/Table
References (24)
Related Citation (15)

Download: PDF (0 KB) HTML (38 KB)
Export: BibTeX | EndNote (RIS)

Abstract

Objective To explore the application value of thrombelastography (TEG) in detection of blood coagulation function in women with gestational diabetes mellitus (GDM).Methods Clinical data of 142 GDM pregnant women who delivered in Chaohu Hospital of Anhui Medical University from October 2017 to October 2019 was were retrospectively analyzed and divided into the GDM group (70 cases) and the control group (72 cases) according to whether the pregnant women had GDM.The routine coagulation function,level of platelet (PLT) and TEG indicators were compared between the two groups.And the correlation analysis was conducted in routine coagulation function indicators and TEG indicators with statistical differences in the GDM group.Results The prothrombin time (PT) in the peripheral blood of the GDM group was longer than that of the control group,the fibrinogen (FIB) was higher than that of the control group,and the differences were statistically significance (P<0.01).The FIB values of the two groups were both higher than the normal range.There were no statistically significant differences in the activated partial thromboplastin time (APTT),thrombin time (TT),D-dimer (DD) and level of PLT between the two groups (P>0.05).The peripheral blood coagulation comprehensive index (CI),maximum amplitude (MA),blood clot mechanical strength (G) and amplitude (A) in the GDM group were higher than those in the control group,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the reaction time (R),coagulation time (K),and clot formation rate (α angle)between the two groups (P>0.05).CI,G and A were positively correlated with PT in GDM group (P<0.05),CI,MA,G and A were positively correlated with FIB in GDM group (P<0.05).Conclusion The blood of women with GDM is prone to form thrombosis,and the thrombus is not easy to fall off.The risk of bleeding in GDM women is also higher than that of normal pregnant women.The TEG indicators are significantly correlated with traditional coagulation indicators.TEG testing for GDM patients is superior to traditional coagulation function detection,which can accurately monitor the patients′ blood status,and provide a basis for clinical anticoagulation and hemostasis.

Key words： Pregnant women Gestational diabetes mellitus Blood coagulation function Thrombelastography Indicator detection

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Ying
	ZHENG Xian-fang
	GE Xiao-hua

Cite this article:

WANG Ying,ZHENG Xian-fang,GE Xiao-hua. Application value of thrombelastography in detection of blood coagulation function in women with gestational diabetes mellitus[J]. 中国当代医药, 2020, 27(30): 75-78.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I30/75

[1]	D′Anna R，Santamaria A，Alibrandi A，et al.Myo-Inositol for the prevention of gestational diabetes mellitus.A brief review[J].J Nutr Sci Vitaminol （Tokyo），2019，65（Supplement）：S59-S61.
[2]	Volanski W，Prado ALD，Al-Lahham Y，et al.d-GDM：A mobile diagnostic decision support system for gestational diabetes[J].Arch Endocrinol Metab，2019，63（5）：524-530.
[3]	陈亚宁.妊娠期糖尿病规范化治疗的应用及妊娠结局分析[J].中国保健营业，2019，29（25）：315-316.
[4]	Facco FL，Parker CB，Reddy UM，et al.Association between sleep-disordered breathing and hypertensive disorders of pregnancy and gestational diabetes mellitus[J].Obstet Gynecol，2017，129（1）：31-41.
[5]	Antza C，Cifkova R，Kotswas V.Hypertensive complications of pregnancy：A clinical overview[J].Metabolism，2018，86：102-111.
[6]	朱怡恬，孙慧谨，汪晓曼，等.不同年龄段妊娠期糖尿病孕妇血小板和凝血参数变化特点及对母儿近期并发症影响[J].现代仪器与医疗，2019，25（6）：49-52.
[7]	Girolami A，Cosi E，Ferrari S，et al.Thrombotic and hemorrhagic conditions due to a gain of function of coagulation proteins：a special type of clotting disorders[J].Clin Appl Thromb Hemost，2018，24（4）：560-565.
[8]	唐浩，傅云峰，桂嵘.孕妇血栓弹力图正常值参考范围的建立[J].中国输血杂志，2017，30（7）：687-689.
[9]	中华医学会妇产科学分会产科学组，中华医学会围产医学分会妊娠合并糖尿病协作组.妊娠合并糖尿病诊治指南（2014）[J].中华妇产科杂志，2014，49（8）：561-569.
[11]	郭欣，吴丽丽，申微，等.高龄孕产妇围生期血脂代谢与凝血功能指标的变化及对妊娠结局的影响[J].中国妇幼保健，2017，32（21）：5231-5233.
[13]	吴秀继，王永卿，何启军.血栓弹力图对妊娠期糖尿病孕妇凝血功能的监测价值[J].山东医药，2018，（58）33：52-54.
[14]	李妮，郑雯雯，王咏梅.妊娠期糖尿病患者凝血功能指标118例分析[J].血栓与止血学，2019，4：620-621.
[15]	罗将来，胡丽娜.凝血功能检测在妊娠期糖尿病孕妇中的意义[J].重庆医学，2016，45（9）：1210-1212.
[10]	Lan XF，Sun YJ.Clinical significance of coagulation function in patients with gestational diabetes mellitus and gestational hypertension[J].Chin J Clin Pathol，2016，33（9）：611-615.
[12]	Shi F，Yu A，Yuan L.Clinical significance of detection of coagulation indexes，immune factors and inflammatory factors in patients with pregnancy-induced hypertension syndrome in China[J].Iran J Public Health，2019，48（4）：681-687.
[16]	Dong C，Gu X，Chen F，et al.The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus[J].J Clin Lab Anal，2020，34（4）：e23129.
[17]	蔡琴.临产孕妇凝血四项检测的临床意义[J].实验与检验医学，2014，32（4）：463-464.
[18]	李明辉，时露.血栓和出血性疾病中血栓弹力图与常规凝血功能检测指标的相关性分析[J].现代医药卫生，2016，32（17）：2703-2704.
[19]	贾佳，杨巧妮，赵子房，等.晚期妊娠合并重度子痫前期患者血栓弹力图特点分析[J].中国医科大学学报，2016，45（12）：1105-1109.
[20]	马品.血栓弹力图和凝血四项评价患者凝血功能对比[J].卫生标准管理，2016，7（16）：148-149.
[21]	陈冠伊，欧阳锡林，吴靖辉，等.血栓弹力图与常规凝血四项评价临床患者凝血功能的对比研究[J].中国实验血液学杂志，2015，23（2）：546-551.
[22]	Ganter MT，Hofer CK.Coagulation monitoring：current techniques and clinical use of viscoelastic point-of-care coagulation devices[J].Anesth Analg，2008，106（5）：1366-1375.
[23]	陈冠伊，欧阳锡林，吴靖辉，等.两种输血方案在择期手术大量输血患者中的应用效果比较[J].海南医学，2015，26（21）：3173-3176.
[24]	田艳，赖冬，董婉妮，等.血栓弹力图在创伤后大出血患者输血治疗中的作用[J].中国输血杂志，2017，30（9）：1024-1026.