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| Application effect of Mifepristone combined with Ethacridine Lactate Injection amniotic cavity injection on induced labor in the second trimester of placenta previa |
| JIN Liang-yi1 ZHANG Qi2 |
1. Department of Obstetrics, Shenyang Maternity Hospital, Liaoning Province, Shenyang 110011, China;
2. Jinzhou Medical University, Liaoning Province, Jinzhou 121000, China |
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Abstract Objective To study the application effect of Mifepristone combined with Ethacridine Lactate Injection amniotic cavity injection on induced labor in the second trimester of placenta previa. Methods A total of 74 patients in Shenyang Maternity Hospital who received induced labors in the second trimester placenta previa from November 2013 to September 2018 were selected as subjects and divided into control group (n=37) and observation group (n=37) according to the random numbers table method. The control group received the amniotic cavity injection Ethacridine Lactate Injection treatment, the obeservation group received the Mifepristone combined with Ethacridine Lactate Injection amniotic cavity injection. The labor outcome, clinical indicators and adverse reactions of induction were compared between the two groups. Results The induction time in the observation group was shorter than that of the control group,the amount of postpartum blood loss in the observation group within 2 and 24 hours after delivery were less than those of the control group, the success rate of labor induction in the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05). The quality of the curettage of the palace in the observation group ([24.80±1.50]mg) was lower than that of the control group ([54.56±3.05]mg), and the difference was statistically significant (t=27.431，P=0.000). The total effective rate of cervical maturity in the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The total rate of placental fetal membrane residue and adhesion in observation group was lower than that in control group, and the difference was statistically significant (P＜0.05). There were no statistically significant differences between the observation group and the control group in the incidence rates of gastrointestinal side effect and soft birth canal damage (P＞0.05). Conclusion Mifepristone combined with Ethacridine Lactate Injection amniotic cavity injection is effective in the second trimester induction labor of placenta previa excluding placental implantation, softens the cervix obviously, shortens the labor course, reduces the maternal pain, reduces the palace to clear the probability and is worthy of clinical application.
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