肺癌合并脑出血的影响因素及其诊断价值

Abstract
Figure/Table
References (19)
Related Citation (15)

Download: PDF (489 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the influencing factors of lung cancer related cerebral hemorrhage (LCRCH) and the diagnostic value of the main factors. Methods Clinical data of 307 patients with lung cancer hospitalized in Dazhou Central Hospital from March 2014 to April 2020 were retrospectively analyzed, including 56 patients with LCRCH in the experimental group and 251 patients with lung cancer in the control group. Single factor analysis and propensity score matching (PSM) were used to screen out the suspected influencing factors. Logistic regression was used to analyze the independent risk factors. Receiver operating characteristic (ROC) curve was drawn and the diagnostic indexes were calculated. Results The results of univariate analysis and PSM showed that platelets (PLT), prothrombin time (PT) and serum tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125 and CA199 were significantly different between the test group and control group (P<0.05). There were no statistically significant differences in gender, age, lung cancer type, activated partial thrombin time (APTT), international standardized ratio (INR), and serum tumor marker neuron specific enolase (NSE), cyto-keratin 19 fragment antigen 21-1 (CyFRA21-1) between the two groups (P>0.05). Logistic regression analysis showed that CEA level was increased (β=0.001, OR=1.001, 95%CI=1.000-1.002), CA199 level was increased (β=0.004, OR=1.004, 95%CI=1.003-1.004) and PT was prolonged (β=0.157, OR=1.170, 95%CI=1.084-1.263) were independent risk factors for LCRCH (P<0.05). The area under ROC curve (AUC) of PT for LCRCH diagnosis was 0.82 (95%CI=0.74-0.89). Conclusion Prolonged PT and elevated CEA and CA199 levels are independent risk factors for LCRCH, and PT can be used as a good indicator for the diagnosis of this disease.

Key words： Lung tumor Cerebral hemorrhage Prothrombin time Carbohydrate antigen 199

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WAN Shaoheng
	LI Zhongyan
	JIAO Xin
	WANG Jiasi

Cite this article:

WAN Shaoheng,LI Zhongyan,JIAO Xin, et al. Influencing factors and diagnostic value of lung cancer related cerebral hemorrhage[J]. 中国当代医药, 2022, 29(20): 166-169.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I20/166

[1]	Gon Y，Todo K，Mochizuki H，et al.Cancer is an independent predictor of poor outcomes in patients following intracerebral hemorrhage[J].Eur J Neurol，2018，25（1）：128-134.
[2]	迟玉玉，宋巧凤，吴寿岭，等.区域性恶性肿瘤人群心脑血管事件危险因素调查分析[J].中华肿瘤防治杂志，2019， 26（6）：359-365.
[3]	Adams HP Jr.Cancer and Cerebrovascular Disease[J].Curr Neurol Neurosci Rep，2019，19（10）：73.
[4]	Cohen-Neamie ZJ，Ganti L，Stead TS，et al.Acute Headache Due to Intracerebral Hemorrhage Secondary to Brain Metastases[J].Cureus，2021，13（8）：e16889.
[5]	Zhao Y，Xie H，Pan C，et al.Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors[J].Neuropsychiatr Dis Treat，2021，17：2729-2738.
[6]	刘利，田攀文.生物标志物在肺癌筛查中的研究进展[J].华西医学，2020，35（1）：78-83.
[7]	覃克敏，秦超，梁志坚，等.肺癌合并脑出血的临床特点分析[J].中华老年心脑血管病杂志，2018，20（9）：953-956.
[8]	Huang G，Chen L，Qin C，et al.Cerebral hemorrhage as the initial manifestation in patients with systemic cancer[J].Int J Neurosci，2018，128（1）：48-54.
[9]	Wei YC，Chen KF，Wu CL，et al.Stroke Rate Increases Around the Time of Cancer Diagnosis[J].Front Neurol，2019， 10：579.
[10]	洪亮，黄行志，郭建荣.不同病理类型肺癌脑转移患者的临床特征及合并脑出血的危险因素分析[J].中国当代医药，2020，27（26）：77-80.
[11]	Lu Q，Chen L，Zeng J，et al.Clinical Features of Liver Cancer with Cerebral Hemorrhage[J].Med Sci Monit，2016，22：1716-1723.
[12]	卢秋红，秦超，黄戈伦，等.直肠癌相关脑出血27例临床分析[J].中国实用内科杂志，2018，38（5）：472-474.
[13]	Richter I，Jirasek T，Havlickova I，et al.The expression of PD-L1 in patients with castrate prostate cancer treated with enzalutamide[J].J BUON，2018，23（6）：1796-1802.
[14]	Gusdon AM，Nyquist PA，Torres-Lopez VM，et al.Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy[J].Stroke，2020，51（1）：129-136.
[15]	王珊珊，王巍伟，潘磊，等.肺癌患者凝血功能变化及其临床意义[J].标记免疫分析与临床，2020，27（10）：1637-1641.
[16]	Qin K，Chen Y，Long H，et al.The biomarkers and potential pathogenesis of lung cancer related cerebral hemorrhage[J].Medicine（Baltimore），2019，98（20）：e15693.
[17]	Navi BB，Reichman JS，Berlin D，et al.Intracerebral and subarachnoid hemorrhage in patients with cancer[J].Neurology，2010，74（6）：494-501.
[18]	Xie X，Chen L，Zeng J，et al.Clinical features and biological markers of lung cancer-associated stroke[J].J Int Med Res，2016，44（6）：1483-1491.
[19]	Shao B，Wahrenbrock MG，Yao L，et al.Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome[J].Blood，2011，118（15）：4015-4023.