重组牛碱性成纤维细胞生长因子联合玻璃酸钠治疗老年白内障术后干眼症患者的效果及对患者泪膜功能、炎症因子的影响

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Abstract Objective To investigate the effect of Recombinant Bovine Basic Fibroblast Grow Factor (rb-bFGF) combined with Sodium Hyaluronate in the treatment of senile patients with dry eye after cataract surgery and its effect on tear film function and inflammatory factors. Methods A total of 76 elderly patients (76 eyes) with dry eye who were underwent cataract surgery in the People′s Hospital of Xintai City from November 2020 to October 2021 were selected as the research subjects, and they were divided into the treatment group (38 cases, 38 eyes) and the control group (38 cases, 38 eyes) by random touching-ball method. The control group was treated with Sodium Hyaluronate, the treatment group was treated with rb-bFGF combined with Sodium Hyaluronate. The clinical efficacy of the two groups were compared, and the tear film function and inflammatory factor levels were compared between the two groups before and after treatment. Results The total effective rate in treatment group was higher than that in control group, and the difference was statistically significant (P<0.05). After treatment, the tear film break-up time (BUT) levles of the two groups after treatment were longer than those before treatment, and the Schirmer Ⅰ test (SⅠt) lengths of the two groups were higher than those before treatment, corneal fluorescein staining (FL) scores of the two groups were lower than those before treatment, and BUT in treatment group after treatment was longer than that in control group, SⅠt in treatment group after treatment was higher than that in control group, FL score in treatment group after treatment was lower than that in control group, the differences were statistically significant (P<0.05). After treatment, the levels of interleukin-1β (IL-1β) and interleukin-8 (IL-8) in the two groups were lower than those before treatment, and compared, the levels of IL-1β and IL-8 in the treatment group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The treatment of rb-bFGF combined with Sodium Hyaluronate in elderly patients with dry eye after cataract surgery can improve the clinical efficacy, improve tear film function and regulate the level of inflammatory factors.

Key words： Recombinant Bovine Basic Fibroblast Grow Factor Sodium Hyaluronate Senile cataract Dry eye Clinical efficacy Tear film function Inflammatory factors

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	YANG Hongyun

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YANG Hongyun. Effect of Recombinant Bovine Basic Fibroblast Grow Factor combined with Sodium Hyaluronate in the treatment of senile patients with dry eye after cataract surgery and its effect on tear film function and inflammatory factors[J]. 中国当代医药, 2022, 29(20): 118-121.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I20/118

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