左炔诺孕酮宫内节育系统联合地屈孕酮在子宫腺肌病中的应用效果

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Abstract Objective To investigate the application effect of Levonorgestrel Intrauterine Contraceptive System with Didroxyprogesterone in adenomyosis (AM). Methods A total of 70 cases of AM patients from the Department of Obstetrics and Gynecology of Yichun People′s Hospital from January 2019 to December 2021 were selected as the study subjects, and they were divided into the study group and the control group, with 35 cases in each group. The patients in the control group were treated with Levonorgestrel Intrauterine Contraceptive System, and the patients in the study group were treated with Levonorgestrel Intrauterine Contraceptive System combined with Didroxyprogesterone. The menstrual situation, uterine situation, sex hormone level, the rate of drip bleeding and accidental exfoliation and the total effective rate were compared between the two groups before and after treatment. Results Before treatment, there were no significant differences in the menstrual volume, pain degree, endometrial thickness and uterine volume between the two groups (P＞0.05). The menstrual volume of the study group after treatment was less than that of the control group, the degree of pain of the study group after treatment was less than that of the control group, and the endometrial thickness and uterine volume of the study group after treatment were less than those of the control group, the differences were statistically significant (P＜0.05). Before treatment, there were no significant differences in the levels of luteinizing hormone (LH), serum follicle stimulating hormone (FSH) and estradiol (E2) between the two groups (P＞0.05). The level of E2 of the study group after treatment was higher than that of the control group, the difference was statistically significant (P＜0.05). The drip bleeding rate and the accidental shedding rate in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05). The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Levonorgestrel Intrauterine Contraceptive System combined with Didroxyprogesterone was effective in treating AM, which can effectively improve the clinical symptoms, prevent adverse events and improve the quality of life.

Key words： Adenomyosis Levonorgestrel Intrauterine Birth Control System Dydrogesterone Therapeutic effect Sex hormone levels Menstrual situation

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