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| Diagnostic value of peripheral blood cystatin C, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with chronic hepatitis B and early renal injury |
| XU Jiao1 ZHANG Ying1 WANG Yuanyuan1 ZHU Feng2▲ |
1.The Six Department of Hepatopathy, Dalian Public Health Clinical Center, Liaoning Province, Dalian 116031, China;
2.The Second Department of Nephrology, Xinhua Hospital Affiliated to Dalian University, Liaoning Province, Dalian 116021, China |
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Abstract Objective To explore diagnostic value of peripheral blood cystatin C (Cys-C), kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with chronic hepatitis B and early renal injury. Methods A total of 56 patients with chronic hepatitis B and early renal injury admitted to Dalian Public Health Clinical Center from April 2018 to April 2021were enrolled as the observation group, while other 56 patients with matched gender and age, and simple chronic hepatitis B during the same period were enrolled as the control group. The levels of estimated glomerular filtration rate (eGFR), Cys-C, KIM-1 and NGAL between the two groups were compared. The detection value of Cys-C, KIM-1 and NGAL levels in patients with chronic hepatitis B and early renal injury and their correlation with eGFR were analyzed. Results The eGFR in the observation group was lower than that in the control group, and the levels of Cys-C, KIM-1 and NGAL in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05). The results of ROC showed that the AUC of serum Cys-C, KIM-1 and NGAL levels in patients with chronic hepatitis B and early renal injury was 0.771, 0.785 and 0.766 respectively, lower than that of combined detection (0.896, P<0.05). The cut-off values of Cys-C, KIM-1 and NGAL were 1.24 mg/L, 1.03 mg/L, 116.82 ng/ml. Cys-C, KIM-1, NGAL levels were negatively correlated with eGFR (P<0.05). Conclusion The levels of serum Cys-C, KIM-1, NGAL and their combined detection have diagnostic value for patients with chronic hepatitis B and early renal injury, which is worthy of clinical reference.
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