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| Changes and analysis of diagnostic value of serum fibrin degradation products and haptoglobin in elderly asthma |
| LIU Yong1 LIU Dan2 CHAI Wenshu3 |
1. Department of Emergency, Jinzhou Central Hospital, Liaoning Province, Jinzhou 121000, China;
2. Department of Respiratory Mediccine, Department of Oncology, Jinzhou Central Hospital, Liaoning Province, Jinzhou 121000, China;
3. Department of Respiratory Medicine, the First Affiliated Hospital of Jinzhou Medical University, Liaoning Province, Jinzhou 121000, China |
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Abstract Objective To explore the changes of serum fibrin degradation products (FDP) and haptoglobin (HPT) in elderly asthma and their diagnostic value. Methods A total of 58 elderly patients with asthma diagnosed and treated in Jinzhou Central Hospital from March 2016 to March 2019 were selected as the asthma group, and 58 volunteers with normal physical examination during the same period were selected as the control group. Pearson method was used to analyze the correlation between FDP and HPT levels and lung function indicators. ROC curve was used to analyze the diagnostic value of FDP and HPT in elderly patients with asthma. Results The forced ventilation volume, forced expiratory volume in the first second and maximum respiratory peak flow rate in the asthma group were lower than those in the control group, the difference was statistically significant (P<0.05). The levels of serum FDP and HPT in the asthma group were higher than those in the control group, the difference was statistically significant (P<0.05). Pearson analysis showed that the levels of serum FDP and HPT in elderly patients with asthma were negatively correlated with the forced ventilation volume, forced expiratory volume in the first second and maximum respiratory peak flow rate (P<0.05). ROC curve showed that the area under the curve (AUC) of serum FDP and HPT levels in the diagnosis of elderly asthma was 0.830 and 0.833 respectively, and the AUC of combined diagnosis of elderly asthma was 0.911. Conclusion Serum FDP and HPT have the potential as early diagnosis and identification indicators for elderly asthma.
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| [1] |
王宇纯.探讨老年哮喘患者的临床控制及肺通气功能的情况[J].中国保健营养，2020，30（24）：136.
|
| [2] |
周莉芳.中老年支气管哮喘患者的流行病学特点及危险因素[J].河南医学研究，2020，29（18）：3346-3348.
|
| [3] |
李宇青，冯高华，成怡楠.FeNO和血清维生素D、白介素-22在哮喘-慢性阻塞性肺疾病重叠综合征患者中的表达及临床意义[J].海南医学，2019，30（2）：150-154.
|
| [4] |
王丽峰，张春芳.哮喘和慢性阻塞性肺疾病重叠综合征患者血清维生素D水平改变及其临床意义[J].检验医学与临床，2016，13（18）：2619-2621.
|
| [5] |
樊胜志，徐浩，张庆桥.血浆D-D、Fib及FDP在肺栓塞治疗中的意义[J].医学研究杂志，2019，48（2）：88-91.
|
| [6] |
张方杰，李湘民，张娟，等.急性胸痛患者血浆D-二聚体，纤维蛋白原和纤维蛋白（原）降解产物的水平[J].中南大学学报（医学版），2019，44（11）：1209-1213.
|
| [7] |
金耀建，温怀凯.肺炎患儿血清中C-反应蛋白、触珠蛋白、铜蓝蛋白、α应蛋酸性糖蛋白的检测及其临床意义[J].中华临床医药杂志，2001，2（7）：57-58.
|
| [8] |
苏晓茹，潘峰，郑高明，等.血清α清明酸性糖蛋白和触珠蛋白在肺结核中的水平测定及结果分析[J].中国卫生检验杂志，2019，29（12）：1469-1471.
|
| [9] |
蒋云秋，张红萍，王蕾，等.老年支气管哮喘的诊断与鉴别诊断[J].中国呼吸与危重监护杂志，2012，11（2）：207-210.
|
| [10] |
斯热吉丁·巴合依.老年人支气管哮喘的临床特点与治疗策略分析[J].临床医药文献电子杂志，2019，6（67）：49.
|
| [11] |
Agondi RC，Andrade MC，Takejima P，et al.Atopy is associated with age at asthma onset in elderly patients[J].J Allergy Clin Immunol Pract，2018，6（3）：865-871.
|
| [12] |
李海彬.急性白血病患者血清LDH、αDH血病患、ADA、D-D及FDP检测的临床价值[J].中国处方药，2020，18（6）：144-145.
|
| [13] |
侯蕊，景永宏.血浆纤维蛋白单体、纤维蛋白降解产物和D二聚体水平的变化在急性白血病中的诊断价值[J].血栓与止血学，2021，27（2）：313-314.
|
| [14] |
刘小莉，张静，张红梅.类风湿关节炎患者血浆FDP和DD水平与疾病活动性的相关性研究[J].现代检验医学杂志，2020，35（2）：60-64.
|
| [15] |
赵玉敏.类风湿关节炎患者血清IgG-RF检验的临床价值探讨[J].检验医学与临床，2020，17（11）：1604-1606.
|
| [16] |
李婕，张鹏，杨正海，等.CA125，纤维蛋白原，纤维蛋白降解产物及D-二聚体在肺结核诊断中的价值[J].沈阳医学院学报，2021，23（3）：240-243.
|
| [17] |
Ren ZH，Zhao XA，Zeng L，et al.Correlation and clinical significance of plasma interleukin-18，-16，-4 rand IFN-γ level in children with asthma and pneumonia[J].Anhui Med Pharm J，2018，22（1）：85-87.
|
| [18] |
高淑平，温旺荣，谭艳玲.慢性阻塞性肺疾病急性加重期伴肺炎患者血清IL-6、HPT、SAA 的检测价值分析[J].国际检验医学杂志，2018，39（12）：1479-1481.
|
| [19] |
施力颖，牟宝华，江婷婷.免疫球蛋白IgG3恒定区和触珠蛋白与肺结核病的相关性分析[J].浙江医学，2017，39（9）：699-702.
|
|
|
|
