不同病理类型肺癌脑转移患者的临床特征及合并脑出血的危险因素分析

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Abstract Objective To investigate the clinical features of different pathological types of lung cancer and brain metastases, and to analyze the risk factors of cerebral hemorrhage. Methods The clinical data of 370 patients with lung cancer and brain metastases who were treated in the General Hospital of Pingxiang Mining Group Co., Ltd. from May 2017 to May 2019 were retrospectively analyzed. The clinical features of different pathological types of lung cancer and brain metastases and the influencing factors of cerebral hemorrhage were analyzed. Results There were significantly statistical differences in the distribution of intracranial lesions, combined hemorrhage and density of lesion among the patients with different pathological types (squamous cell carcinoma, adenocarcinoma, small cell carcinoma, large cell carcinoma, adenosquamous carcinoma) of lung cancer and brain metastases (P＜0.05). The patients were divided into the hemorrhage group (n=154) and the non-hemorrhage group (n=216) according to the hemorrhage of patients. The results of single-factor analysis showed that the proportions of high density or mixed density of multiple lesions and tumor in the hemorrhage group were higher than those in the non-hemorrhage group, the differences were statistically significant(P＜0.05). Multiple-factor analysis showed that the high density or mixed density of multiple lesions (β=1.959, OR=7.091, 95%CI=4.442-11.320) and tumor (β=0.740, OR=2.095, 95%CI=1.376-3.190) were the risk factors of cerebral hemorrhage in patients with lung cancer and brain metastases (P＜0.05). Conclusion The lung cancer patients with different pathological types have different clinical features of brain metastases, and the risk of cerebral hemorrhage can be estimated based on the clinical features of patients.

Key words： Lung cancer Pathological types Brain metastases Multiple lesions Mixed density

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	HONG Liang
	HUANG Xing-zhi
	GUO Jian-rong

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HONG Liang,HUANG Xing-zhi,GUO Jian-rong. Clinical features of patients with different pathological types of lung cancer and brain metastases and the risk factors of cerebral hemorrhage[J]. 中国当代医药, 2020, 27(26): 77-80.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I26/77

[1]	陶丽军.肺癌脑转移患者临床分析[J].中国实用神经疾病杂志，2015，18（17）：31-32.
[2]	吴俊兰，范兴文，王洪兵，等.EGFR 突变肺癌患者脑转移空间分布特征及海马转移风险分析[J].中华放射肿瘤学杂志，2019，28（11）：817-820.
[3]	汤晓梅，易向军，张莉.外泌体在促进非小细胞肺癌脑转移中的作用[J].医学影像学杂志，2019，26（14）：56-59.
[4]	闫安，李春红，孙贤，等.肺癌脑转移预后的多因素分析[J].现代生物医学进展，2015，15（12）：2319-2322.
[5]	李媛秋，刘剑君，么鸿雁.肺癌发病和死亡流行情况与人类发展指数的关系分析[J].中国肿瘤，2019，28（9）：646-650.
[6]	孙可欣，郑荣寿，曾红梅，等.2014年中国肺癌发病和死亡分析[J].中华肿瘤杂志，2018，40（11）：805-811.
[7]	张永芹，左云，钱普东，等.228 例肺癌脑转移患者的临床观察[J].临床肿瘤学杂志，2018，23（6）：548-552.
[8]	安云霞，张群成，轩伟霞，等.以脑转移为首发的肺癌患者的临床特点及预后影响因素分析[J].实用癌症杂志，2018，33（5）：801-804.
[9]	骆竹媚.非小细胞肺癌脑转移患者预后多因素Cox 回归分析[J].临床肺科杂志，2015，20（4）：627-630.
[10]	龚星，陈国庆.脑放疗联合靶向治疗与同步放、化疗治疗非小细胞肺癌脑转移对疾病控制率及中位生存期的影响分析[J].当代医学，2018，24（15）：18-20.
[11]	刘燕，赵凌云，房敏.以神经系统症状为首发的肺癌脑转移42 例临床治疗体会[J].中国实用神经疾病杂志，2018，21（7）：784-786.
[12]	程国芬，骆成，刘海波.不同病理类型肺癌脑转移瘤的CT 平扫及增强扫描特征[J].癌症进展，2018，16（7）：834-836，840.
[13]	王生海，吴鹏，陈海海，等.肺癌脑转移合并出血的影像特征及其与病理类型的相关性[J].中国临床医学影像杂志，2015，26（9）：609-611，615.
[14]	刘倩倩，杨卫华.肺癌脑转移治疗研究进展[J].肿瘤研究与临床，2019，31（3）：201-205.
[15]	焦玉新，任艳萍.定量影像学在肺癌放/化疗疗效评估中的应用[J].中国肺癌杂志，2017，20（6）：407-414.