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| Effect of 3.0% hypertonic saline in treatment of hypovolemic shock caused by multiple fractures of limbs |
| CHEN Ming SUN Tong |
| Surgical Intensive Care Unit, Affiliated Zhongshan Hospital of Dalian University, Liaoning Province, Dalian 116000,China |
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Abstract Objective To explore the effect of 3.0% hypertonic saline in treatment of hypovolemic shock caused by multiple fractures of limbs. Methods A total of 86 cases with hypovolemic shock caused by multiple fracture of limbs admitted in our hospital from February 2019 to January 2020 were selected as the research objects. They were divided into two groups according to the random number table method, with 43 cases in each group. The control group was given Hydroxyethyl Starch 130/0.4 Injection and Lactated Ringer′s solution immediately, the observation group was given 3% hypertonic saline supplement. The electrolyte levels, plasma osmotic pressure and cerebral oxygen partial pressure levels during the treatment, and the mini-mental state examination (MMSE) scores within 12 hours after operation were compared between the two groups. Results After treatment, the sodium ion and chloride ion levels in the observation group were higher than those in the control group, and the potassium ion level was lower than that in the control group, the differences were statistically significant (P＜0.05); at 30 min, 2 h and 12 h after treatment, the plasma osmotic pressure and cerebral oxygen partial pressure in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). At 12 h after treatment, the MMSE score in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion To treat patients with hypovolemic shock caused by multiple fractures of limbs with 3.0% hypertonic saline is of great value to maintain plasma electrolyte balance, increase plasma osmotic pressure, ensure cerebral oxygen supply, improve nerve function to a certain extent.
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