Objective To explore the application effect of online and offline training courses for family caregivers in elderly family caregivers. Methods The convenience sampling method was adopted to select 101 trainees from two classes of a vocational qualification training course for primary family caregivers in Binjiang District, Hangzhou in March 2021 as the research objects, 51 trainees from one class as the experimental group, and 50 trainees from the other class as the control group. The experimental group adopted the mixed teaching mode, while the control group adopted the traditional teaching mode. The knowledge questionnaire scores and course satisfaction ratings of family caregivers were compared between the two groups. Results The scores of life care, basic care and rehabilitation service of the trained family caregivers in the experimental group were higher than those in the control group, the differences were statistically significant (P<0.05). The satisfaction of experimental group was better than that of control group, and the difference was statistically significant (P<0.05). Conclusion Compared with traditional teaching mode, blended teaching mode can effectively improve theoretical knowledge and satisfaction of family caregivers.