帕博利珠单抗联合培美曲塞+顺铂化疗方案在晚期肺腺癌中的应用效果

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Abstract

Objective To observe the clinical effect and safety of Pembrolizumab combined with Pemetrexed and Cisplatin (AP) chemotherapy in the treatment of advanced lung adenocarcinoma. Methods A total of 78 patients with locally advanced and advanced lung adenocarcinoma admitted to Department of Medical Oncology of Suzhou Hospital Affiliated to Nanjing Medical University from June 2018 to June 2020 were enrolled as the research objects retrospectively.According to different treatment methods, they were divided into AP chemotherapy group (n=37) and combination group(n=41). AP chemotherapy group was treated with AP chemotherapy (Pemetrexed 500 mg/m2 + Cisplatin 75 mg/m2),while combination group was treated with Pembrolizumab (200 mg) on basis of AP regimen. The curative effect, score of quality of life (QOL), progression-free survival (PFS), progression-free survival rate within 1 year and adverse reactions during treatment were compared between the two groups. Results The disease remission rate and disease control rate in combination group were higher than those in AP chemotherapy group, the differences were statistically significant (P<0.05). Improvement rate of quality of life in the combination group was higher than that in AP chemotherapy group, the difference was statistically significant (P<0.05). The progression-free survival rate within 1 year in combination group was higher than that in AP chemotherapy group, and PFS was longer than that in AP chemotherapy group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). Conclusion The short-term curative effect of Pembrolizumab combined with AP chemotherapy is more ideal, which can prolong survival time of patients to a certain extent, with few adverse reactions.And it provides new direction for clinical treatment of patients with advanced lung adenocarcinoma.

Key words： Advanced lung adenocarcinoma Pemetrexed Cisplatin Pembrolizumab

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