玉泉丸治疗精神分裂症伴代谢综合征的临床研究

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Abstract Objective To explore the influence of Yuquan Pills on blood glucose，blood lipid and blood pressure in schizophrenic patients with metabolic syndrome.Methods A total of 80 schizophrenic patients with metabolic syndrome from June to December 2019 in Nanchang 334th Hospital were selected and divided into the control group and the observation group according to the random number table method，40 cases in each group.Both groups maintained the original antipsychotic treatment，the observation group was given Yuquan Pills treatment，the control group was given equal dose placebo.The levels of blood glucose，blood lipid，body mass index (BMI) and blood pressure were compared between the two groups.Results There were no significant differences in the levels of fasting blood glucose (FBG)，2-hour postprandial blood glucose (2 h PG)，triglyceride (TG)，high-density lipoprotein (HDL)，BMI，diastolic blood pressure and systolic blood pressure between the two groups before treatment (P＞0.05).After treatment，the levels of FPG([5.04±0.89]mmol/L)，2 h PG ([6.63±1.05]mmol/L) in the observation group were lower than those in the control group([7.23±1.05]mmol/L，[9.48±1.63]mmol/L)，and the differences were statistically significant (P＜0.05).The levels of TG([1.24±0.21]mmol/L) and BMI ([23.55±2.86]kg/m2) in the observation group after treatmrnt were lower than those in the control group ([1.93±0.34]mmol/L，[26.74±3.12]kg/m2)，and the level of HDL ([1.34±0.23]mmol/L) in the observation group after treatment was higher than that in the control group ([0.96±0.15]mmol/L)，and the differences were statistically significant (P＜0.05).The levels of diastolic blood pressure ([80.14±4.29]mmHg) and systolic blood pressure([121.45±7.05]mmHg) in the observation group after treatment were lower than those in the control group ([86.74±5.12]mmHg，[128.45±7.53]mmHg)，the differences were statistically significant (P＜0.05).Conclusion Yuquan Pills can reduce the blood pressure level of schizophrenia patients with metabolic syndrome，improve the metabolism of glucose and lipid，reduce the body weight and promote the improvement of the disease.

Key words： Schizophrenia Metabolic syndrome Yuquan Pills Blood lipid Blood glucose Blood pressure

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PAN Xiao-wen. Clinical study of Yuquan Pills in the treatment of schizophrenia with metabolic syndrome[J]. 中国当代医药, 2020, 27(33): 73-75转79.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I33/73

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