宫颈小细胞神经内分泌癌临床病理特征分析

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Abstract Objective To investigate the clinicopathological and immunohistochemical features of small cell neuroendocrine carcinoma of the cervix （SCCC）.Methods A total of 5 cases of SCCC patients were collected and studied by light microscope and immunohistochemistry from May 2006 to March 2020 in Bao′an District People′s Hospital in Shenzhen City.Results The histology of 5 cases showed that the tumor cells were small and round or sunflower-like，the cytoplasm was sparse，the nucleolus was not easy to be seen，and the tumor cells grew in mosaic-like nests.Immunohistochemistry showed that 5 cases expressed at least 2 kinds of neuroendocrine markers(Syn，CGA and CD56)，2 cases diffusely expressed TTF-1，5 cases of CD117 were negative.Conclusion SCCC has unique clinicopathologic and immunohistochemical features，and immunohistochemistry plays an important role in the diagnosis and differential diagnosis.SCCC specifically expresses more than one neuroendocrine marker，TTF-1 has no significance in the differential diagnosis of cervical metastasis between primary SCCC and non-small cell carcinoma，CD117 has some significance in the differential diagnosis of both.

Key words： Small cell carcinoma of cervix Neuroendocrine carcinoma Immunohistochemistry Differential diagnosis

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	Articles by authors
	LIU Bing-ying
	LIU Yu-hong
	LI Xiao-ming

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LIU Bing-ying,LIU Yu-hong,LI Xiao-ming. Analysis on the clinicopathological features of small cell neuroendocrine carcinoma of the cervix[J]. 中国当代医药, 2020, 27(33): 32-35.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I33/32

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