氯沙坦与卡托普利治疗高血压肾病的临床效果比较

Abstract
Figure/Table
References (19)
Related Citation (9)

Download: PDF (416 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the clinical effects of Losartan and Captopril in the treatment of hypertensive nephropathy.Methods A total of 60 patients with hypertensive nephropathy admitted to the Department of Cardiology of the First Hospital of Putian From July 2020 to June 2021 were selected as the research subjects,they were divided into Losartan group and Captopril group by drawing lots method,with 30 cases in each group.Two groups of patients were treated with Losartan and Captopril respectively.The systolic and diastolic blood pressures,estimated glomerular filtration rate(eGFR),the difference between the eGFR(△eGFR)before and after treatment and the total incidence of complications during the treatment were compared between the two groups.The blood creatinine levels of the two groups were collected and were used for the calculations of the eGFR.Results Before treatment,there were no significant differences in systolic blood pressure,diastolic blood pressure,and eGFR between the two groups(P＞0.05).After treatment,the systolic blood pressure of the two groups was lower than that before treatment,and the systolic blood pressure of the Losartan group was lower than that of the Captopril group,the differences were statistically significant(P＜0.05).After treatment,the diastolic blood pressure of the two groups was lower than that before treatment,and the diastolic blood pressure of the Losartan group was lower than that of the Captopril group,the differences were statistically significant(P＜0.05).After treatment,the eGFR of the two groups was higher than that before treatment,and the eGFR of the Losartan group was higher than that of the Captopril group,the differences were statistically significant(P＜0.05).After treatment,△eGFR in the Losartan group was higher than that of the Captopril group,and the difference was statistically significant(P＜0.01).The total incidence of the complications in the Losartan group(13.30%)was lower than that in the Captopril group(36.70%),the difference was significant(P=0.037).Conclusion From the effect of lowering blood pressure and improving renal function,both drugs can reduce blood pressure,improve renal function and reduce the incidence of adverse drug reactions,thereby preventing the progression of renal disease.Losartan is better than Captopril in the treatment of hypertensive nephropathy.

Key words： Hypertensive nephropathy Losartan Captopril Glomerular filtration rate

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIN Xiujuan
	CHEN Jinzao
	ZHENG Liru

Cite this article:

LIN Xiujuan,CHEN Jinzao,ZHENG Liru. Comparisons of the clinical effect of Losartan and Captopril in the treatment of hypertensive nephropathy[J]. 中国当代医药, 2022, 29(10): 128-131.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I10/128

[1]	黄震华，徐济民.新型抗高血压药物氯沙坦[J].中国新药与临床杂志，1998（2）：47-48.
[2]	郑剑卿，谢秀梅，余国龙.氯沙坦对老年轻、中度原发性高血压的肾脏保护作用[J].湖南医学，2000，17（6）：464-465.
[3]	梅长林.氯沙坦肾脏保护作用的临床研究[J].中华高血压杂志，2007，15（S1）：50-52.
[4]	刘先霞，宋钦华.氯沙坦对早期糖尿病肾病高血压和肾功能的影响[J].中国现代医学杂志，2002，12（5）：79-81.
[5]	陈建华.国内外的高血压诊断标准[J].中华实用中西医杂志，2010，23（4）：33-34.
[6]	王晓菁，陈海平.慢性肾脏病定义及分期系统修订的进展--2012-KDIGO 慢性肾脏病临床管理实践指南解读[J].中华老年多器官疾病杂志，2014，13（5）：396-400.
[7]	叶继伦.无创血压测量技术与有效的评价方法[J].中国医疗器械杂志，2007，31（6）：439-442.
[8]	邓春美，刘伟霞，孙大英，等.冠心病合并中重度肾功能不全患者并发其他疾病的临床分析[J].中国医药指南，2016，14（25）：88.
[9]	程武，连国军.血清肌酐测定方法学进展及其评价[J].中国保健，2009，17（15）：562-565.
[10]	Parra G，Rodríguez-Iturbe B，Colina-Chourio J，et al.Shortterm treatment with captopril in hypertension due to acute glomerulonephritis[J].Clin Nephrol，1988，29（2）：58-62.
[11]	吴茂金，吴贵杰，陈彪.卡托普利对高血压患者早期肾损害的影响[J].中国误诊学杂志，2003，3（5）：676-677.
[12]	李斌，段智娟，梁艳，等.氯沙坦钾治疗充血性心力衰竭疗效分析[J].现代诊断与治疗，2003，14（4）：225-226.
[13]	秦又发，田海红，孙飞，等.氯沙坦对两肾一夹高血压大鼠肾脏的保护作用及PRCP-激肽释放酶调节轴的影响[J].药学学报，2013，48（1）：59-65.
[14]	全正莉，李贞琼，刘建社.氯沙坦对糖尿病大鼠肾组织TLR4 表达的影响[J].临床肾脏病杂志，2007，7（2）：82-83，插页.
[15]	吕丽萍.卡托普利与氯沙坦治疗肾性高血压临床观察[J].山西医药杂志，2007，36（2）：163-164.
[16]	季洪赞，杨俊中，乔小云.氯沙坦与福辛普利、卡托普利对老年高血压患者尿白蛋白排泄量和内生肌酐清除率的对比研究[J].中国循环杂志，2001，16（1）：37-38.
[17]	许永坚.氯沙坦对老年高血压患者肾功能的保护作用[J].临床医药实践杂志，2008，17（2）：120-122.
[18]	金仲品，韩淑梅，王翠平.卡托普利不良反应的综合报道[J].药物不良反应杂志，2004（2）：101-105.
[19]	范晓燕.氯沙坦治疗轻、中度高血压病的疗效和分析观察[J].家庭心理医生，2014，10（11）：237.