肿瘤坏死因子-α基因多态性与首发抑郁症及舍曲林疗效的关联研究

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Abstract Objective To investigate the association between tumor necrosis factor-α (TNF-α) gene polymorphism with first-episode depression and efficacy of Sertraline. Methods A total of 265 inpatients and out-patients with firstepisode depression diagnosed and treated in Binzhou Youfu Hospital from June 2011 to June 2018 were selected as the case group. In addition, 380 healthy blood donors from Binzhou City and surrounding counties were selected as the control group. Each genotype polymorphism loci of patients with first-episode depression and healthy subjects was analyzed by the polymerase chain reaction-restriction fragment length polymorphism. SHEsis online software was used to analyze the differences in genotype distribution and allele distribution of TNF-α -G238A (rs361525)、-G308A (rs 1800629)、-C857T (rs1799724)、-C863A (rs1800630). Curative effect of 265 patients with first-episode depression treated with Sertraline after eight weeks was evaluated with Hamilton rating scale for depression (HAMD). Results Significant difference was shown in frequency distribution of genotypes and alleles of TNF-α gene rs1800629 between case group and control group (P＜0.05); after Bonferroni correction, difference in frequency distribution of genotype was still significant (P＜0.05). There was no significant difference in the frequency distribution of genotypes and alleles of rs361525 and rs1799724, rs1800630 between two groups (P＞0.05). There was no significant difference in frequency of haploid type between case group and control group (P＞0.05). After 8 weeks of Sertraline treatment, the chi-square test was used to analyze the relationship between the frequency distribution of alleles and genotypes of the 4 SNPS polymorphisms of TNF-α gene and the efficacy of Sertraline in patients with first-episode depression, the results showed that there was no significant difference in frequency distribution of genotype in rs1800629 between effective group and ineffective group (P＞0.05); significant difference was shown in frequency distribution of allele in rs1800629 between two groups (P＜0.05). After Bonferroni correction, no significant difference was shown in frequency distribution of allele in rs1800629 between effective group and ineffective group (P＞0.05). Significant difference was shown in frequency distribution of genotypes and alleles of TNF-α gene rs361525 between effective group and ineffective group (P＜0.05),after Bonferroni correction, difference in frequency distribution of genotypes and alleles in rs361525 was still significant(P＜0.01). There was no statistically significant difference in genotype and allele frequency distribution of rs1800630 and rs1799724 between the effective group and the ineffective group (P＞0.05). There was no significant difference in frequency of haploid type between effective group and ineffective group (P＞0.05). Conclusion TNF-α gene rs1800629 polymorphism may be associated with the susceptibility of first-episode depression, rs361525 polymorphism may be associated with the efficacy of Sertraline.

Key words： First-episode depression Tumor necrosis factor-α Sertraline Single-nucleotide polymorphism

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	LIU Yu-zhi
	KOU Hai-yan

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LIU Yu-zhi,KOU Hai-yan. Research of tumor necrosis factor-α gene polymorphisms associated with first-episode depression and the efficacy of Sertraline[J]. 中国当代医药, 2020, 27(26): 17-23.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I26/17

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