最低剂量艾司氯胺酮联合右美托咪定对全麻术后患者复苏效果和咽喉痛的影响

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Abstract Objective To explore the effect of minimum dose of Esketamine combined with Dexmedetomidine on resuscitation and sore throat after general anesthesia.Methods A total of 90 patients who underwent elective endotracheal intubation in the Department of Anesthesiology,the Fifth Affiliated Hospital of Guangzhou Medical University from October 2020 to June 2021 were selected as the research subjects,and were divided into control group(n=45)and observation group(n=45)according to random number table method.The control group was continuously pumped with Remifentanil and Dexmedetomidine,while the observation group was continuously pumped with the lowest dose of Esketamine and Dexmedetomidine.The recovery time and extubation time were compared between the two groups.The changes of circulatory indexes in two groups were observed before administration(T0),at extubation(T1),and at 0.5 h(T2)and 1 h(T3)after administration.Ricker sedative-agitation score(SAS)was compared between the two groups after awakening.The related complications in the resuscitation period of patients in the two groups were analyzed.The visual analogue scale(VAS)score of wound at exit,6 h after surgery and the VAS score of sore throat at 12 h after surgery were evaluated.Results There were no significant differences in the recovery time and extubation time between two groups(P＞0.05).The HR of observation group at T2 and T3 were higher than those of control group,the differences were statistically significant(P＜0.05).There was no significant difference in MAP between the two groups at each time point(P＞0.05).There was no significant difference in SAS score between two groups after awakening(P＞0.05).There were no drug-related complications in the recovery period in both groups.There was no significant difference in VAS score between the two groups at exit and 6 h after surgery(P＞0.05).While the sore throat VAS score at 12 h after operation in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The minimal dose Esketamine and Dexmedetomidine intravenous injection does not affect the recovery time and extubation time of patients,and stabilizes the cardiovascular system.There are no psychotic side effects.It can also effectively inhibit postoperative wound pain and sore throat.In the recovery period of anesthesia,the administration scheme can be used as an alternative to opiates,which is worth clinical reference.

Key words： Esketamine Dexmedetomidine Recovery quality Postoperative sore throat

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	Articles by authors
	JIN Yongqiang
	ZHANG Nini
	ZHOU Wenfeng
	ZHANG Lei
	GUO Lin
	TANG Jing

Cite this article:

JIN Yongqiang,ZHANG Nini,ZHOU Wenfeng, et al. Effect of minimum dose of Esketamine combined with Dexmedetomidine on resuscitation and sore throat after general anesthesia[J]. 中国当代医药, 2022, 29(10): 5-09.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I10/5

[1]	Mahiswar AP，Dubey PK，Ranjan A.Comparison be tween dexmedetomidine and fentanyl bolus in attenuating the stress response to laryngoscopy and tracheal intubation：a randomized double-blind trial[J].Braz J Anesthesiol，2021，72（1）：103-109.
[2]	Elmeligy MSM，Elmeliegy MFM.Effect of Magnesium Sulfate Nebulization on Stress Response Induced Tracheal Intubation;Prospective，Randomized Study[J].Open J Anesthesiol，2021，11（4）：128-135.
[3]	Lee J，Lee YC，Son JD，et al.The effect of lidocaine jelly on a taper-shaped cuff of an endotracheal tube on the postoperative sore throat：a prospective randomized study：A CONSORT compliant article[J].Medicine（Baltimore），2017，96（37）：122-126.
[7]	Jauncey M，Nielsen S.Naloxone for opioid toxicity and overdose in the community[J].Aust Prescr，2021，44（2）：38-39.
[4]	Sulser S，Ubmann D，Brueesch M，et al.The C-MAC video laryngoscope compared with conventional laryngoscopy for rapid sequence intubation at the emergency department：study protocol[J].Scand J Trauma Resusc Emerg Med，2015，4（24）：23-38.
[10]	朱明明，刘芳，王冉，等.躁动镇静评分在重症患者中应用的研究进展[J].中华护理杂志，2018，53（2）：247-250.
[11]	伏永艳.疼痛评分表的制作与临床应用[J].护理实践与研究，2016（12）：137-138.
[13]	陈艳艳，庄国栋，高明.右美托咪定神经保护作用机制的研究进展[J].中国实验诊断学，2021，25（1）：141-144.
[5]	Brian AB.Toxicities of opioid analgesics：respiratory depression，histamine release，hemodynamic changes，hypersensitivity，serotonin toxicity[J].Arch Toxicol，2021，95（8）：10-16.
[6]	Luz M，Mash DC.Evaluating the toxicity and therapeutic potential of ibogaine in the treatment of chronic opioid abuse[J].Expert Opin Drug Metab Toxicol，2021，17（9）：1019-1022.
[8]	Bornemann CH，Wejbora M，Michaeli K，et al.The effects of minimal-dose versus low-dose S-ketamine on opioid consumption，hyper-algesia and postoperative delirium：a tripleblinded，randomized，active and placebo controlled clinical trial[J].Minerva Anestesiol，82（10）：1069-1076.
[12]	Seth R，Koppalli SS，Nadav D，et al.Recent Advances in Peripheral Opioid Receptor Therapeutics[J].Curr Pain Headache Rep，2021，25（7）：46-47.
[16]	Snijdelaar DG，Cornelisse HB，Schmid RL，et al.A randomised，controlled study of peri-operative low doses（+）-ketamine in combination with postoperative patient-controlled s（+）-ketamine and morphine after radical prostatectomy[J].Anaesthesia，2020，59（3）：222-228.
[17]	Choi J，Kim S.Delayed awakening time from general anesthesia for dental treatment of patients with disabilities[J].J Dent Anesth Pain Med，2021，21（3）：219-226.
[18]	王璐，丁文刚.右美托咪定对心脏作用研究的进展[J].心血管康复医学杂志，2020，29（6）：717-719.
[19]	Kim YU，Cho BH，Cho HR.Comparison of Intracuff Pressure and Postoperative Sore Throat Following Use of Laryngeal Mask Airway Protector With or Without Nitrous Oxide Anesthesia[J].J Perianesth Nurs，2021，36（3）：247-252.
[15]	康艺涵，朱尤壮，秦上媛，等.艾司氯胺酮的研究进展[J].中国医师进修杂志，2021，44（5）：470-476.
[9]	刘克，徐伟民，林泉，等.艾司氯胺酮和右美托咪定在小儿增强CT 检查中的镇静效果比较[J].中国新药与临床杂志，2021，40（7）：511-514.
[14]	裴圣林，荆忍，潘灵辉.全身麻醉药对癌症转移、复发的影响研究进展[J].中国癌症防治杂志，2021，13（2）：113-120