抗凝治疗对复发性流产伴子宫动脉阻力指数增高患者血栓前状态和妊娠结局的影响

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Abstract Objective To investigate the effect of anticoagulant therapy on prethrombotic state and pregnancy outcome in patients with recurrent abortion and increased uterine artery resistance index.Methods A total of 120 patients with recurrent miscarriage with increased uterine artery resistance index admitted to Ji′an Maternity and Child Health Hospital from January to December 2020 were selected as research objects.They were divided into observation group and control group according to random number table method,with 60 cases in each group,all patients began to use drugs after vaginal color Doppler ultrasound prompts early intrauterine pregnancy(within 5 weeks of pregnancy).The control group was given Dydrogesterone Tablets and Vitamin E Capsules.The observation group was treated with Low-molecular-weight Heparin Calcium on the basis of the control group.The changes of resistance index(RI),prethrombotic state indexes(D-dimer[DD],thrombin time[TT],antithrombin Ⅲ[ATⅢ]activity)and pregnancy activity rate were compared between the two groups before and after treatment.Results The RI score of the observation group after treatment was lower than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,DD in the observation group was lower than that in the control group,and TT and ATⅢwere higher than those in the control group,and the differences were statistically significant(P＜0.05).The live birth rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion Anticoagulant therapy can effectively reduce RI,improve prethrombotic state and pregnancy outcome in patients with recurrent abortion and increased uterine artery resistance index.

Key words： Anticoagulant therapy Recurrent abortion Uterine artery resistance index Prethrombotic state index Pregnancy outcome

Received: 12 October 2021

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