金黄色葡萄球菌表面蛋白与生物被膜关系的研究进展

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Abstract Staphylococcus aureus and Staphylococcus epidermidis are the most important pathogens of biofilm related infection of indwelling medical devices. Staphylococcus aureus surface proteins Ebh,SasF,SasG,aggregation factor B(ClfB),biofilm associated protein(Bap)and fibronectin/fibrinogen binding protein are involved in the formation of biofilm matrix,respectively.This large number of proteins intervene in different stages of biofilm formation.Some proteins contribute to the accumulation of biofilm,while others mediate the primary attachment of biofilm surface.This paper reviews the role and regulatory mechanism of surface proteins in biofilm formation of Staphylococcus aureus,in order to provide a theoretical basis for the prevention and treatment of biofilm infection.

Key words： Staphylococcus aureus Surface protein Biofilm Infection

Received: 30 September 2021

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