腹腔镜结肠癌根治术联合术后洛铂腹腔热灌注化疗对结肠癌患者全身各系统的影响

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Abstract Objective To investigate the effect of laparoscopic radical resection of colon cancer combined with intraperitoneal hyperthermic perfusion chemotherapy of Lobaplatin on the safety of postoperative blood routine,liver function,renal function,and postoperative complications in patients with colon cancer.Methods A total of 100 patients with colon cancer admitted to the First People′s Hospital of Zhaoqing from January 2018 to January 2021 were retrospectively selected as the research objects.The patients who underwent laparoscopic radical colon cancer surgery combined with intraperitoneal hyperthermic perfusion chemotherapy with Lobaplatin were set as the observation group,and the patients who underwent laparoscopic radical colon cancer surgery alone were set as the control group,with 50 cases in each group.The blood routine,liver function,renal function,immune infection indexes,and postoperative recovery time of exhausting and defecation,food taking,hospital stay,and complication rate were compared between the two groups before and at 3 and 5 d after operation.Results Before operation and 3,5 d after operation,there were no significant differences in the levels of white blood cell(WBC),hemoglobin(HGB)or platelet(PLT)between the two groups(P＞0.05).At 3 and 5 d after operation,the levels of WBC and PLT of the two groups were higher than those before operation,and the HGB was lower than that before operation,with statistical significance(P＜0.05).Before operation and 3,5 d after operation,there were no significant differences in the level of alanine aminotransferase(ALT)or aspartate aminotransferase(AST)between the two groups(P＞0.05).There were no significant differences in AST at 3 d after operation and ALT at 5 d after operation in the two groups compared with those before operation(P＞0.05).The ALT at 3 d after operation and AST at 5 d after operation in the two groups were higher than those before operation,the differences were statistically significant(P＜0.05).Before operation and 3,5 d after operation,there was no significant difference in blood urea nitrogen(BUN)or serum creatinine(SCr)between the two groups(P＞0.05).There was no significant difference in the BUN or SCr of the two groups at 3 and 5 d after operation compared with those before operation(P＞0.05).Before operation and 5 d after operation,there was no significant difference in C-reactive protein(CRP)between the two groups(P＞0.05).Compared with the control group,the CRP in the observation group was higher than the control group at 3 d after operation,and the difference was statistically significant(P＜0.05).The CRP of the two groups at 3 and 5 d after the operation was higher than that before the operation,and the difference was statistically significant(P＜0.05).The recovery time of exhausting and defecation as well as taking food in observation group was longer than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences between the two groups in postoperative complications and the number of rehospitalization one month after operation(P＞0.05).Conclusion Laparoscopic radical resection of colon cancer combined with Lobaplatin intraperitoneal hyperthermic perfusion chemotherapy is safe and feasible in the treatment of patients with colon cancer.It has litter influence on the blood system,liver function,and renal function,but did have effect on gastrointestinal system.It will not increase the incidence of postoperative complications.

Key words： Laparoscopic radical resection of colon cancer Perioperative period Intraperitoneal hyperthermic perfusion chemotherapy Lobaplatin Efficacy Complications

Received: 19 November 2021

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[1]	郑荣寿，孙可欣，张思维，等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志，2019，41（1）：19-28.
[2]	Hohenberger W，Weber K，Matzel K，et al.Standardized surgery for colonic cancer：complete mesocolicexcision and central ligation-technical notes andoutcome[J].Colorectal Dis，2009，11（4）：354-364.
[3]	吴引兵，巴明臣，崔书中，等.Ⅲ、Ⅳ期胃癌腹腔热灌注化疗临床疗效与安全性Meta分析[J].中华肿瘤防治杂志，2013，20（21）：1686-1690.
[4]	刁德昌，卢新泉，何耀彬，等.动脉优先入路法腹腔镜右半结肠癌根治术的可行性及应用价值[J].中华胃肠外科杂志，2017，20（1）：90-93.
[5]	郭建琰，杨远胡.右美托咪定复合罗哌卡因腹横肌平面阻滞应用于腹腔镜结肠癌根治术加速康复外科中的价值评价[J].中国医药科学，2021，11（24）：111-114.
[6]	Piso P，Stierstorfer K，Gerken M，et al.Benefit of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in patients with isolated peritoneal metastases from colorectal cancer[J].Int J Colorectal Dis，2018，33（11）：1559-1567.
[7]	李雁，周云峰，梁寒，等.细胞减灭术加腹腔热灌注化疗治疗腹膜表面肿瘤的专家共识[J].中国肿瘤临床，2015，42（4）：198-206.
[8]	Spratt JS，Adcock RA，Muskovin M，et al.Clinical delivery system for intraperitoneal hyperthermic chemotherapy[J].Cancer Res，1980，40（2）：256-260.
[9]	中国抗癌协会腹膜肿瘤专业委员会，广东省抗癌协会肿瘤热疗专业委员会.中国腹腔热灌注化疗技术临床应用专家共识（2019 版）[J].中华医学杂志，2020，100（2）：89-96.
[10]	Engel JB，Martens T，Hahne JC，et al.Effects of lobaplatin as a single agent and in combination with TRAIL on the growth of triple-negative p53 mutated breast cancersin vitro[J].Anticancer Drugs，2012，23（4）：426-436.
[12]	杨龙龙，尹清臣，李忠信，等.微创手术联合术后腹腔热灌注化疗对进展期食管胃交界部腺癌患者细胞免疫因子及肿瘤标志物的影响[J].中国内镜杂志，2020，26（6）：14-19.
[13]	李仕卿，彭茜，杨朝纲，等.不同治疗模式对结直肠癌腹膜转移的疗效比较[J].武汉大学学报（医学版），2020，41（5）：758-762.
[14]	吴川清，李源，王点石，等.腹腔热灌注化疗治疗胃癌腹膜转移的安全性及有效性单中心临床研究[J].临床外科杂志，2020，28（5）：424-428.
[15]	纪飞虹，董新华，常伟龙，等.腹腔镜手术联合术后洛铂腹腔热灌注对Ⅲ、Ⅳ期胃癌免疫功能的影响及疗效评估[J].河南外科学杂志，2018，24（5）：14-17.
[11]	Sartore-Bianchi A，Trusolino L，Martino C，et al.Dual-targeted therapy with trastuzumab and lapatinib in treatment refractory，KRAS codon 12/13 wild-type，HER2-positive metastatic colorectal cancer（HERACLES）：A proof-ofconcept，multicentre，open-label，phase 2 trial[J].Lancet Oncol，2016，17（6）：738-746.
[16]	余中林，周业江.术后腹腔热灌注洛铂联合SOX 案静脉化疗应用于局部进展期直肠癌的安全性评估[J].实用医学杂志，2019，35（14）：2281-2287.