牛白藤饮片质量标准研究

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Abstract Objective Develop quality standards for Hedyotis hedyotidea Chinese Herbal Pieces.Methods Hedyotis hedyotidea is a rubiaceae plant Hedyotis hedyotidea(DC.).Dried vine stem,Twelve batches of Chinese Herbal Pieces samples came from four traditional Chinese medicine decoction pieces companies in Hu′nan Province.To improve of thin layer chromatography(TLC)method for identification of Hedyotitis Hedyotidea.Add water content,total ash check items,according to the 2020 edition of Chinese Pharmacopoeia,the second method of moisture determination,determination of total ash content of samples by ash determination method,Average moisture,120% of the mean of total ash,control limit of moisture and total ash.Determine the content of water-soluble extract according to the extract determination method,the control limit of the extract was calculated by 80% of the average value of the extract.Results The improved TLC method was more efficient.The average water content of 12 batches of Hedyotis Hedyotidea samples was 12.67%,the recommended moisture limit was "not to exceed 15.0%";the mean value of total ash was 8.71%,it was recommended that the total ash limit be set at "not more than 11.0%";the mean value of water-soluble extract was 16.04%,it was recommended that the extract limit be set at "not less than 13.0%".Conclusion The water and total ash examination items were added,the TLC improved the examination efficiency,and the determination of the extract was more suitable to the clinical practice.It provides the basis for Hedyotis Hedyotidea Chinese Herbal Pieces quality standard improvement.

Key words： Hedyotis hedyotidea Chinese Herbal Pieces Thin layer chromatography Moisture Total ash Extractives Quality standards

Received: 23 September 2021

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