|
|
|
| Effect of Glucocorticoid,Cyclophosphamide Combined with Sildenafil in treatment of connective tissue disease complicated with pulmonary hypertension(CTD-PAH) |
| JU Yan-juan1 GUO Di-bin1 ZHOU Xu-feng2▲ SUN Jian-fang1 |
1.Department of Rheumatology and Immunology,the First Hospital Affiliated to Gannan Medical College in Jiangxi Province,Ganzhou 341000;
2.The Second Department of Heart,the First Hospital Affiliated to Gannan Medical College in Jiangxi Province,Ganzhou 341000 |
|
|
|
|
Abstract ObjectiveTo investigate the effect of Glucocorticoid,Cyclophosphamide Combined with Sildenafil in treatment of connective tissue disease complicated with pulmonary hypertension (CTD-PAH).Methods70 patients with CTD-PAH treated in our hospital from December 2015 to February 2016 were selected as the study objects,and they were divided into two groups according to the number random method,and there were 35 cases in each group.The control group was treated with Sildenafil alone,and the observation group was given combined Cyclophosphamide and Glucocorticoids therapy on the basis of the control group.Clinical effect,pulmonary artery systolic pressure level and adverse reactions were observed in the two groups.ResultsTotal effective rate of the observation group was 97.14%,which was significantly higher than that of the control group(80.00%)(χ2=5.081,P=0.024).Systolic pulmonary arterial pressure level was significantly lower than that of the control group (P＜0.05),and walking distance of 6 min was significantly longer than that in the control group (P＜0.05).The incidence of adverse reactions in the observation was 5.71%,which was significantly lower than of that of the control group (22.86%)(χ2=4.200,P=0.040).ConclusionGlucocorticoid,Cyclophosphamide Combined with Sildenafil treatment of connective tissue disease complicated with pulmonary hypertension(CTD-PAH)
|
|
|
|
|
|
| [9] |
薛静，刘磊，吴华香.结缔组织病合并肺动脉高压64例临床及预后分析[J].中华内科杂志，2013，52（2）：166-167.
|
| [10] |
张宏民，刘大为，王小亭，等.系统性红斑狼疮合并心力衰竭、呼吸衰竭、肺动脉高压一例[J].中国医学科学院学报，2013，35（4）：472-474.
|
| [12] |
陈果，何建国，柳志红，等.不同类型肺动脉高压患者临床特征和血流动力学的比较分析[J].中国循环杂志，2013，28（4）：300-303.
|
| [13] |
周伯炜.结缔组织病继发肺动脉高压的诊治[J].中国药物与临床，2013，13（1）：93-95.
|
| [1] |
杨丽丽，刘冬梅，崔华东，等.结缔组织病合并肺动脉高压15 例回顾分析[J].中国实用儿科杂志，2013，26（12）：928-931.
|
| [2] |
罗东萍，刘秀梅，傅自力，等.灯盏花素联合糖皮质激素及环磷酰胺治疗系统性红斑狼疮并发肺动脉高压的疗效观察[J].中西医结合心脑血管病杂志，2016，14（14）：1682-1684.
|
| [3] |
Hassoun PM，Zamanian RT，Damico R，et al.Ambrisentan and tadalafil up-front combination therapy in sclerodermaassociated pulmonary arterial hypertension[J].Am J Respir Crit Care Med，2015，192（9）： 1102-1110.
|
| [4] |
王治国，刘学明，佟胜全.糖皮质激素、环磷酰胺联合西地那非用于系统性红斑狼疮合并肺动脉高压患者临床效果观察[J].山东医药，2016，59（28）：42-44.
|
| [5] |
李园园，胡克.血小板计数及N-末端脑钠肽前体等实验室指标在结缔组织病伴发肺动脉高压中的临床意义[J].中华实用诊断与治疗杂志，2016，30（3）：228-230.
|
| [7] |
顾晴，熊长明，柳志红，等.结缔组织病合并肺栓塞的临床特征及误诊原因分析[J].中华医学杂志，2015，95（2）：120-122.
|
| [8] |
郝燕捷，高兰，丁文惠，等.结缔组织病相关肺动脉高压的早期诊断与治疗[J].中华临床医师杂志（电子版），2014，8（23）：92-96.
|
| [6] |
Sobanski V，Launay D，Hachulla E，et al.Current approaches to the treatment of systemic-sclerosis-associated pulmonary arterial hypertension （SSc-PAH）[J].Curr Rheumatol Rep，2016，18（2）：1-14.
|
| [11] |
Ramjug S，Hussain N，Hurdman J，et al.Long-term outcomes of domiciliary intravenous iloprost in idiopathic and connective tissue disease-associated pulmonary arterial hypertension[J].Respirology，2017，22（2）：372-377.
|
| [14] |
黄石安，罗鹏，吴源聪，等.GTP结合蛋白α亚基11在肺动脉高压大鼠肺无肌动脉肌化过程中的表达及西地那非的干预作用 [J].中华医学杂志，2016，96 （22）：1762-1765.
|
| [15] |
王治国，刘学明，石哲群，等.系统性红斑狼疮合并肺动脉高压 46例临床分析 [J].中国综合临床，2016，32（10）：892-895.
|
|
|
|
