|
|
|
| Analysis of Professor Wei Lianbo′s clinical medication rule in the treatment of chronic renal failure based on data mining |
| HU Fen1 HU Juan2▲ YANG Yanqun3 WANG Ziwei3 WEI Lianbo3 |
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine
2. Institute Office, the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine
3. Department of Traditional Chinese Medicine, Shenzhen Hospital of Southern Medical University |
|
|
|
|
Abstract Objective To explore the clinical medication rule of Professor Wei Lianbo in the treatment of chronic renal failure. Methods Based on the software of Traditional Chinese Medicine Inheritance Support System V2.5, the database was constructed, and the data mining method of software integration was used to analyze the syndrome, drug frequency and prescription rules of prescriptions. Results A total of 396 prescriptions met the inclusion criteria, involving 125 traditional Chinese medicines. The four qi of medicine were mainly warm, cold and mild heat. The five flavors of the medicine were mainly bitter, sweet, pungent and sour. The main meridian tropism of drugs were spleen, stomach, liver,lung and kidney. The syndrome was based on deficiency of spleen and kidney and marked by dampness and turbid toxin stasis. Salvia miltiorrhiza, Atractylodes macrocephala, rhubarb, Ligusticum chuanxiong, Pinellia ternata, Amomum villosum, Codonopsis pilosula, tangerine peel, Coptis chinensis, dried ginger, Achyranthes bidentata and Eucommia ulmoides were the core drug groups, which were mainly used to strengthen spleen and stomach, promote blood circulation and remove blood stasis, and nourish liver and kidney. Conclusion Professor Wei Lianbo′s treatment of chronic renal failure follows the principle of strengthening the body and removing pathogenic factors, treating both the symptoms and the root causes. He uses warm, cold and calm heat in his medication, and mostly uses invigorating the spleen and promoting blood circulation, tonifying the liver and kidney. The compatibility of each medicine plays the role of tonifying the spleen and kidney, clearing away dampness,heat and resolving turbidity.
|
|
|
|
|
|
| [1] |
葛均波，徐永健，王辰.内科学[M].北京：人民卫生出版社，2018：518.
|
| [2] |
Zhang L，Wang F，Wang L，et al.Prevalence of chronic kidney disease in China：a cross-sectional survey[J].Lancet，2012，379（9818）：815-22.
|
| [3] |
国家药典委员会.中华人民共和国药典：一部[M].北京：中国医药科技出版社，2020.
|
| [4] |
中华人民共和国卫生部药典委员会.中华人民共和国卫生部药品标准[M].北京：人民卫生出版社，1992.
|
| [5] |
国家技术监督局.中医临床诊疗术语.证候部分：GB/T16751.2-1997[S].北京：国家标准出版社，1997：1-41.
|
| [6] |
国家中医药管理局.24 个专业92 个病种中医临床路径[S].北京：国家中药管理局，2017.
|
| [7] |
张静美，陈晓阳，秦庆广，等.基于数据挖掘与网络药理学探讨徐学功治疗冠心病PCI 术后中药使用规律与作用机制[J].中医药导报，2021，27（8）：148-153.
|
| [8] |
巢元方.诸病源候论[M].北京：中国医药科技出版社，2021：124.
|
| [9] |
李用粹.证治汇补[M].北京：人民卫生出版社，2020：386.
|
| [10] |
郑艳，王圣治，梁亮，等.肾衰方对慢性肾衰竭大鼠微炎症状态影响[J].辽宁中医药大学学报，2019，21（2）：31-33.
|
| [11] |
聂峰，陈国宝，杨爱成.魏连波教授中西医结合治疗慢性肾衰竭经验[J].中医药信息，2005，22（4）：57-58.
|
| [12] |
冯涛，陈杰彬，李成杰，等.补脾益肾、清利化浊法治疗岭南地区CKD2-3 期临床疗效观察[J].数理医药学杂志，2012，25（3）：296-299.
|
| [13] |
郜枫，黄飞.党参对气血亏虚型慢性肾衰竭2～3 期患者贫血及血清纤维化指标的影响[J].临床肾脏病杂志，2015，15（9）：555-559.
|
| [14] |
冯星，邱细敏，黄亚林，等.平江白术多糖对腺嘌呤致大鼠肾衰模型的保护作用[J].食品科学，2010，31（9）：276-278.
|
| [15] |
汪泉，张燕敏，陈伟栋，等.丹参酮ⅡA 对慢性肾衰大鼠肾病理损伤及肾间质纤维化的影响[J].中国临床药理学杂志，2019，35（20）：2609-2612.
|
| [16] |
张玲，熊维建，张太君.黄连碱对慢性肾功能衰竭大鼠的治疗作用及其机制研究[J].中国现代应用药学，2017，34（1）：30-33.
|
| [17] |
巴元明，胡刚明，王林群，等.熟大黄不同煎煮时间对慢性肾功能衰竭影响的实验研究[J].时珍国医国药，2019，30（12）：2912-2915.
|
| [18] |
朱俊.基于数据挖掘王钢教授辨治慢性肾衰竭临床经验研究[D].南京：南京中医药大学，2020.
|
|
|
|
