|
|
|
| Effect of Ziprasidone combined with computer cognitive correction therapy on cognitive function in adolescent schizophrenic patients |
| SONG Liu1 YU Suwei2 |
1. Ward Five, the Fourth People's Hospital of Yingkou City, Liaoning Province, Yingkou 115000, China;
2. Department of Psychology, Yingkou First Specialized Hospital, Liaoning Province, Yingkou 115000, China |
|
|
|
|
Abstract Objective To investigate the effect of Ziprasidone combined with computer cognitive correction therapy on cognitive function in adolescent patients with schizophrenia (SCH). Methods A totla of 94 adolescent SCH patients who admitted to the Fourth People's Hospital of Yingkou City from November 2019 to November 2020 were selected as the research objects and divided into the study group and the reference group by random number table method, with 47 cases in each group. The reference group was treated with Ziprasidone, and the study group was treated with computer cognitive correction on the basis of the reference group. The cognitive function and clinical effect of the two groups were compared. Results Before treatment, there was no statistically significant difference in the indexes of Wisconsin card classification test analysis system (WCST) between the two groups (P＞0.05). After treatment, the number of wrong responses and persistent errors in the two groups were lower than those before treatment, the number of completed classification and correct responses were higher than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, the number of wrong response and persistent error in the study group were lower than those in the reference group, the number of completed classification and correct response were higher than those in the reference group, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the total number of responses between the two groups before and after treatment (P＞0.05). The total effective rate of study group was higher than that of reference group, and the difference was statistically significant (P＜0.05).Conclusion Ziprasidone combined with computer cognitive correction therapy has a better effect on the improvement of cognitive function in adolescent SCH patients, which is worthy of clinical application.
|
|
|
|
|
|
| [1] |
张森.首发青少年精神分裂症患者默认模式网络及其与认知功能缺陷的相关性研究[D].新乡：新乡医学院，2020：34-35.
|
| [2] |
于振东.浅析齐拉西酮对首发精神分裂症患者认知功能的影响[J].中国卫生标准管理，2018，9（3）：93-94.
|
| [3] |
陈涛，许锦泉，吴志雄，等.齐拉西酮和氟哌啶醇对首发精神分裂症患者的疗效及对认知功能和QTc 间期的影响[J].中国医学创新，2020，17（9）：137-140.
|
| [4] |
孙志刚，李素水，王灵君，等.齐拉西酮对首发精神分裂症患者认知功能影响的Meta 分析[J].中国健康心理学杂志，2017，22（7）：964-969.
|
| [5] |
韩鹏，王菲，杨丹，等.计算机认知矫正治疗对女性缓解期精神分裂症患者认知功能的影响[J].中国医科大学学报，2019，48（3）：216-219.
|
| [6] |
席杨.齐拉西酮联合改良电抽搐治疗女性精神分裂症的疗效及对患者认知功能的影响[J].中国民康医学，2017，13（29）：9-11.
|
| [7] |
王俊，杜云红，刘建萍.齐拉西酮片联合氯氮平治疗难治性精神分裂症疗效及对认知功能的影响[J].国际精神病学杂志，2019，46（2）：260-262.
|
| [8] |
Grant DA，Berg EA.A behavioural analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem[J].J Exp Psychol，1984，38（4）：404-411.
|
| [9] |
Kay SR，Fiszbein A，Opler LA.The Positive and Negative Syndrome Scale （PANSS） for schizophrenia[J].Schizophr Bull，1987，13（2）：261-276.
|
| [10] |
尚秀妍.计算机认知矫正治疗对精神分裂症患者认知功能的影响[J].临床医药文献电子杂志，2018，5（48）：51.
|
| [11] |
徐杨，王惠玲，兰燕.齐拉西酮联合无抽搐电休克治疗难治性精神分裂症的临床效果观察[J].解放军预防医学杂志，2017，35（4）：383-385.
|
| [12] |
严文琼，陈立勇，陈新河.认知知觉功能障碍训练联合齐拉西酮对慢性精神分裂症患者认知功能、社会功能的影响[J].中国医药科学，2018，008（015）：20-23.
|
| [13] |
袁强.甲磺酸齐拉西酮注射液对精神分裂症急性激越症状患者PANSS-EC、BARS 评分及不良反应的影响[J].中国当代医药，2020，27（31）：73-75.
|
| [14] |
董勇，杨洪亮，墩雪菲.齐拉西酮与奥氮平治疗早期精神分裂症的临床效果比较[J].中国现代医生，2020，58（11）：135-138.
|
| [15] |
刘华强.齐拉西酮缓释剂联合氯氮平对难治性精神分裂症患者认知功能的影响[J].四川解剖学杂志，2018，26（2）：43-44，50.
|
| [16] |
陈海萍，章秋萍，张丽娜，等.计算机认知矫正治疗对慢性精神分裂症患者认知功能及社会功能水平的影响[J].护理与康复，2018，17（2）：78-80.
|
| [17] |
磨丽莉，石广念，周芳珍，等.计算机认知矫正治疗对老年抑郁症病人认知功能的影响[J].护理研究，2020，34（16）：144-147.
|
| [18] |
陈柳利，许锦泉，陈健，等.齐拉西酮联合认知矫正治疗对青少年精神分裂症的疗效及对认知功能与社会功能的影响[J].临床医学，2021，41（1）：61-63.
|
|
|
|
