吡柔比星及多西他赛联合新辅助化疗在年轻乳腺癌患者中的应用效果

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Abstract Objective To investigate the efficacy of Pyrorubicin and Docetaxel combined with neoadjuvant chemotherapy in young breast cancer,and the effect on prognosis,expression of cancer tissue proliferative nuclear antigen Ki-67(Ki-67),human epidermal growth factor receptor(Her-2)and vascular endothelial growth factor(VEGF)in cancer tissues.Methods A total of 90 young breast cancer patients admitted to Tieling Central Hospital from January 2015 to August 2017 were selected as research subjects.They were divided into combined group and control group by computer random number table method,with 45 cases in each group.The control group received Docetaxel chemotherapy,while the combined group received Pyrorubicin and Docetaxel combined with neoadjuvant chemotherapy.The clinical efficacy of the two groups was compared.The expressions of Ki-67,Her-2,VEGF and the levels of T lymphocyte subsets (CD3+,CD4+,CD8+,CD4+/CD8+) of patients in the two groups before and after treatment were compared.The prognosis (3-year disease-free survival rate [DFS],overall survival period [OS]) of patients in the two groups was compared.Results The total effective rate in combined group was higher than that in control group,the difference was statistically significant(P＜0.05).The positive rates of Ki-67 and VEGF in the combined group were 22.22% and 37.78%,respectively,lower than 51.11% and 62.22% in the control group,with statistical significances (P＜0.05).There was no significant difference in the positive rate of Her-2 between the two groups after treatment (P＞0.05).The 3-year DFS and OS of the combined group were 93.33% and 97.78%,respectively,which were higher than those of the control group of 73.33%and 82.22%,respectively,the differences were statistically significant (P＜0.05).There were no significant differences in the levels of various T lymphocyte subsets before treatment between the two groups (P＞0.05).After treatment,CD3+,CD4+,CD4+/CD8+ were lower than those before treatment,while CD8+ level was higher than that before treatment,the differences were statistically significant (P＜0.05).After treatment,CD3+,CD4+and CD4+/CD8+in combined group were higher than those in control group,while CD8+ was lower than that in control group,the differences were statistically significant (P＜0.05).Conclusions The Pyrorubicin and Docetaxel combined with neoadjuvant chemotherapy in young breast cancer patients can achieve ideal short-term efficacy and prognosis,and can reduce the expression levels of Ki-67 and VEGF to a certain extent,and enhance the immune function of the body.

Key words： Breast cancer Pyrorubicin Docetaxel Neoadjuvant chemotherapy Tumor marker

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CAO Dan. Application effect of Pyrorubicin and Docetaxel combined with neoadjuvant chemotherapy in young breast cancer patients[J]. 中国当代医药, 2022, 29(3): 82-85.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I3/82

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