羊水污染合并新生儿窒息动脉血乳酸及生化因子的水平变化及临床意义

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Abstract Objective To explore and analyze the changes and clinical significance of arterial blood lactic acid and biochemical factors in amniotic fluid contaminated with neonatal asphyxia.Methods From March 2017 to March 2021,120 neonates with amniotic fluid pollution admitted to the Department of Obstetrics and Gynecology and Department of Neonatology in Fuzhou Maternal and Child Health Hospital were selected as the research objects,and they were divided into Ⅰdegree pollution group (43 cases) and Ⅱdegree pollution group (40 cases) and Ⅲdegree pollution group (37 cases) according to the degree of amniotic fluid pollution.A total of 38 cases with neonatal asphyxia were divided into mild asphyxia group (25 cases) and severe asphyxia group (13 cases) according to the degree of asphyxia,and the rest were non-asphyxia group (82 cases).Another 45 neonates without amniotic fluid contamination were selected as the control group.The levels of arterial blood lactic acid and biochemical factors in different amniotic fluid contaminated group and control group were compared.The correlation between the degree of amniotic fluid contamination and arterial blood lactic acid was analyzed.The incidence of neonatal asphyxia in different amniotic fluid contaminated groups was compared.The arterial blood lactic acid levels of neonates in different asphyxia groups were compared at different time after birth.Results The lactic acid values of umbilical artery blood in the Ⅰdegree pollution group,Ⅱdegree pollution group and Ⅲdegree pollution group were higher than those of the control group,the umbilical artery blood lactic acid values in the Ⅱdegree pollution group,Ⅲdegree pollution group were higher than Ⅰdegree pollution group,the lactic acid value of the umbilical artery in the Ⅲdegree pollution group was higher than that in the Ⅱdegree pollution group,and the differences were statistically significant (P＜0.05).Pearson correlation analysis showed that the degree of amniotic fluid pollution was positively correlated with arterial lactic acid level (P＜0.05).The total asphyxiation rate of the Ⅲdegree pollution group was higher than that of the Ⅰdegree pollution group and theⅡdegree pollution group,and the differences were statistically significant (P＜0.05).The arterial blood lactic acid values of the three groups 24 h after birth were lower than those at birth,6,12 h after birth,the arterial blood lactic acid values of the three groups 12 h after birth were lower than those at birth,6 h after birth,the arterial blood lactic acid values of the three groups 6 h after birth were lower than those at birth,and the differences were statistically significant (P＜0.05).The arterial blood lactic acid values of neonates in the severe asphyxia group and mild asphyxia group at birth,6,12,24 h after birth were higher than those of the non-asphyxia group,the arterial blood lactic acid values of neonates in the severe asphyxia group at birth,6,12,24 h after birth were higher than those of the mild asphyxia group,and the differences were statistically significant (P＜0.05).Conclusion As the degree of amniotic fluid pollution increases,the umbilical artery blood lactate value also increases.The incidence of neonatal asphyxia is closely related to the degree of amniotic fluid pollution.The more severe the amniotic fluid pollution,the greater the neonatal asphyxia rate.

Key words： Amniotic fluid pollution Neonatal asphyxia Umbilical artery blood Lactic acid Biochemical factors

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	Articles by authors
	HUANG Shengcai
	QU Liyan
	HUANG Chao
	HE Jiang
	AI Jianjun
	HU Hai
	LI Haiyan

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HUANG Shengcai,QU Liyan,HUANG Chao, et al. Changes and clinical significance of arterial blood lactic acid and biochemical factors in amniotic fluid contaminated with neonatal asphyxia[J]. 中国当代医药, 2022, 29(3): 8-12.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I3/8

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