血清铁调素水平在脑梗死首发患者中的表达及临床意义

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (34 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the expression and clinical significance of serum ferritin level in patients with initial cerebral infarction. Methods A total of 117 patients with cerebral infarction from October 2017 to August 2019 were selected as the observation group and 117 healthy people as the control group.Serum samples were obtained on 1,3,5,7,14 d and 28 d to detect the levels of hepcidin,observation group were further divided into light group (n=42)，moderate group (n=41) and heavy group (n=34) according to their NIHSS scores.The modified Rankin scale (mRS) was evaluated at 3 months after cerebral infarction.According to the mRS scores,the patients were divided into good prognosis group (n=64) and poor prognosis group (n=53).The changes of serum ferritin level were compared between the observation group and the control group at different time points.The relationship between serum hepcidin level and neurological deficit and prognosis in the observation group was analyzed. Results The levels of serum ferritin in the observation group were higher than those in the control group on the 1,3,5,7,14 d and 28 d after the onset of the disease (P<0.05).The levels of light,moderate and heavy serum ferritin in the observation group were higher than those in the control group,and the levels of moderate and heavy serum ferritin were higher than those in the light group,the level of heavy serum ferritin was higher than that in the moderate group,and the differences were statistically significant (P<0.05).In the observation group,the levels of serum ferritin water on the 1,3,5,7,14 d and 28 d after the onset of the disease were lower than those of the patients with poor prognosis,the differences were statistically significant(P<0.05).Conclusion After cerebral infarction,the expression of serum ferritin increased,and the more serious the degree of neurological impairment,the worse the prognosis,the more obvious the expression,the level of serum ferritin is closely related to the occurrence,severity and prognosis of cerebral infarction.

Key words： Cerebral infarction Serum hepcidin Expression；Clinical significance

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SUN Yu
	HE Xing-Ling
	YANG Shui-quan

Cite this article:

SUN Yu,HE Xing-Ling,YANG Shui-quan. Expression and clinical significance of serum ferritin level in patients with initial cerebral infarction[J]. 中国当代医药, 2020, 27(21): 64-66.

URL:

https://dangdaiyiyao.com/EN/ OR https://dangdaiyiyao.com/EN/Y2020/V27/I21/64

[1]	Azmin S，Osman SS，Mukari S，et al.Cerebral amyloid angiopathy：an important differential diagnosis of stroke in the elderly[J].Malays J Med Sci，2015，22（1）：74-78.
[2]	Garcia-Yebenes I，Sobrado M，Moraga A，et al.Iron overload，measured as serum ferritin，increases brain damage induced by focal ischemia and early reperfusion[J].Neurochem Int，2012（61）：1364-1369.
[3]	Reichert CO，da Cunha J，Levy D，et al.Hepcidin：homeostasis and diseases related to iron metabolism[J].Acta Haematol，2017,137（4）：220-236.
[4]	Zhao Y，Xin Z，Li N，et al.Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism[J].Free Radic Biol Med，2018，8（20）：124.
[5]	赵晋英，李艳伟.铁代谢红细胞系调节因子与铁稳态[J].中国生物化学与分子生物学报，2019，35（5）：486-492.
[6]	中华神经科学会，中华神经外科学会.各类脑血管疾病诊断要点[J].中华神经科杂志，1996，29（6）：379-380.
[7]	Ois A，Martinez-Rodriguez JE，Munteris E，et al.Steno-occlusive arterial disease and early neurological deterioration in acute ischemic stroke[J].Cerebrovasc Dis，2008（25）：151-156.
[8]	张世洪，吴波.谈颂卒中登记研究中指数和改良的量表的适用性与相关性研究[J].中国循证医学杂志，2004，4（12）：871-874.
[9]	Yang L，Zhang B，Yin L，et al.Tanshinone ⅡA prevented brain iron dysshomeostasis in cerebral ischemic rats[J].Cell Physiol Biochem，2011，27（1）：23-30.
[10]	顾杰.脑出血患者血清铁蛋白水平与脑水肿发生的相关性[J].心脑血管病防治，2016，16（3）：200-202.
[11]	Ganz T，Nemeth E.Hepcidin and iron homeostasis[J].BBAMol Cell Res，2012，1823（9）：1434-1443.
[12]	Ding H，Yan CZ，Shi H，et al.Hepcidin is involved in iron regulation in the ischemic brain[J].PLoS One，2011（6）：e25324.
[13]	孔德燕，黄振华，王凯华.急性缺血性脑卒中患者血清铁调素25 及铁代谢指标变化及临床意义[J].中华老年心脑血管病杂志，2015，17（5）：455-458.
[14]	GanzT，NemethE.Hepcidinanddisordersofironmetabolism[J].Annu Rev Med，2011，62：347-360.
[15]	Habib A，Polavarapu R，Karmali V，et al.Hepcidin-ferroportin axis controls toll-like receptor 4 dependent macrophage inflammatory responses in human atherosclerotic plaques[J].Atherosclerosis，2015，241（2）：692-700.