抑酸剂联合促胃动力药治疗稳定期COPD合并胃食管反流的效果

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Abstract ObjectiveTo observe the effects of proton pump inhibitor(PPI)combined with gastric motility drugs in the treatment of stable chronic obstructive pulmonary disease (COPD)and gastroesophageal reflux disease(GERD).Methods 90 outpatients with stable COPD and GERD in our hospital from March 2015 to March 2016 were selected and divided into the control group and the intervention group respectively according to the order of treatment.The original treatment about COPD was not changed for both groups and the intervention group was treated with Omeprazole(20 mg,po bid)and Mosapride(5 mg,po tid)for 8 weeks additionally.The reflux diagnostic questionnaire(RDQ)score,St George′s respiratory questionnaire (SGRQ)score,lung function (FEV1%pred)and 6 minute walk distance (6MWD)were compared between the two groups before and after treatment.ResultsCompared with the control group,the RDQ score,each part and the total score of SGRQ in intervention group after treatment was significant lower(P＜0.05),while FEV1%pred and 6MWD had no significant change(P＞0.05).The RDQ score was negatively correlated with FEV1%pred and 6MWD before and after treatment in the two groups,while positively correlated with the score of SGRQ (P＜0.05).ConclusionTreatment with PPI combined with gastric motility drugs can improve clinical symptoms and life quality of patients with COPD coexisting with GERD.

Key words： Chronic obstructive pulmonary disease Gastroesophageal reflux disease St George&prime s respiratory questionnaire

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	HE Bingl
	WEI Hai-long

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HE Bingl,WEI Hai-long. Effect of proton pump inhibitor combined with gastric motility drugs in the treatment of stable COPD complicated with gastroesophageal reflux[J]. 中国当代医药, 2017, 24(23): 37-39.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I23/37

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