疏肝健脾方联合恩替卡韦治疗肝郁脾虚证乙肝肝硬化患者的临床效果

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Abstract Objective To explore the clinical effect of Shugan Jianpi Recipe combined with Entecavir in the treatment of hepatitis B cirrhosis patients with syndrome of of liver depression and spleen deficiency.Methods A retrospective analysis of 76 cases of hepatitis B cirrhosis patients with syndrome of of liver depression and spleen deficiency from October 2018 to October 2020 in the First Affiliated Hospital of Hunan College of Chinese Medicin was conducted.The patients were divided into the conventional group (n=36)and the combined group (n=40)according to the treatment plan.The conventional group was given Entecavir,and the combined group was given Shugan Jianpi Recipe on the basis of the conventional group.The treatment efficacy,the scores of traditional Chinese medicine syndrome,liver function,liver fibrosis,cellular immune function before and 3 months after treatment,hepatitis B virus DNA content(HBV DNA)negative rate and the total incidence of adverse reactions of the two groups were compared.Results The total effective rate of the combined group was higher than that of the conventional group,the difference was statistically significant(P＜0.05).After treatment,the scores of traditional Chinese medicine syndromes in the two groups were lower than those before treatment,the differences were statistically significant(P＜0.05).And the scores of traditional Chinese medicine syndromes in the combined group after treatment was lower than the conventional group,the differences were statistically significant(P＜0.05).The levels of total bilirubin (TBIL),aspartate aminotransferase(AST),hyaluronic acid(HA),laminin(LN),pre-Ⅲ collagen peptide(PC-Ⅲ),type Ⅳ collagen(Ⅳ-C),cytotoxic T cell(CD8＋)after treatment in the two groups were lower than those before treatment,and the levels of TBIL,AST,HA,LN,PC-Ⅲ,Ⅳ-C,CD8＋of the combined group after treatment were lower than those of the conventional group,the differences were statistically significant(P＜0.05).After treatment,the levels of albumin(ALB),mature T lymphocytes(CD3＋),and helper T cells(CD4＋)after treatment in the two groups were higher than those before treatment,and the levels of ALB、CD3＋、CD4＋of the combined group after treatment were higher than those of the conventional group,the differences were statistically significant(P＜0.05).After treatment,the HBV DNA negative ratio in the combined group was higher than that in the conventional group,the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Shugan Jianpi Recipe combined with Entecavir tablets in the treatment of liver depression and spleen deficiency syndrome of hepatitis B cirrhosis patients has ideal clinical effect,which can alleviate the clinical symptoms of patients,protect liver function,improve cellular immune function.

Key words： Shugan Jianpi Recipe Entecavir Syndrome of liver depression and spleen deficiency Hepatitis B cirrhosis

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	LIU Feng
	LI Ming
	CHEN Kai-feng
	YUAN Tong-li

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LIU Feng,LI Ming,CHEN Kai-feng, et al. Clinical efficacy of Shugan Jianpi Recipe combined with Entecavir in the treatment of hepatitis B cirrhosis patients with syndrome of liver depression and spleen deficiency[J]. 中国当代医药, 2021, 28(31): 173-176转180.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I31/173

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