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| Effect of Compound Danshen Dripping Pills combined with Valsartan on blood pressure and vascular endothelial function in elderly patients with essential hypertension |
| ZHAN Jian YU Huang-peng |
| Department of Pharmacy,the Third People′s Hospital of Jiujiang City,Jiangxi Province,Jiujiang 332000,China |
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Abstract Objective To investigate the effect of Compound Danshen Dripping Pills combined with Valsartan on blood pressure and vascular endothelial function in elderly patients with essential hypertension.Methods A total of 92 elderly patients with essential hypertension admitted to the Third People′s Hospital of Jiujiang City from February 2019 to February 2020 were selected as subjects.They were divided into the Western medicine group and the combination group according to the random number table method,with 46 patients in each group.Both groups were given Aspirin Enteric-coated Tablets and Atorvastatin Calcium Tablets after admission.The Western medicine group were given oral Valsartan to control blood pressure,and the combination group were treated with Compound Danshen Dripping Pills combined with Valsartan.The systolic blood pressure,diastolic blood pressure,serum nitric oxide(NO),and endothelin(ET-1)levels before and after treatment,and clinical efficacy were compared between the two groups.Results Before treatment,there were no statistically significant differences in blood pressure indicators between the two groups (P＞0.05).After treatment,the blood pressure indicators in the two groups were lower than those before treatment,with statistically significant differences (P＜0.05).The blood pressure indicators in the combination group after treatment were lower than those in the Western medicine group,with statistically significant differences(P＜0.05).The total effective rate of the combination group was higher than that in the Western medicine group,with statistically significant difference(P＜0.05).Before treatment,there were no significant differences in vascular endothelial function indexes(NO,ET-1)between the two groups(P＞0.05).After treatment,the NO levels in the two groups were higher than those before treatment,and the ET-1 levels in the two groups were lower than those before treatment,with statistically significant differences (P＜0.05).After treatment,the NO level in the combination group was higher than that in the Western medicine group,and ET-1 level in the combination group was lower than that in the Western medicine group,with statistically significant differences(P＜0.05).Conclusion Compound Danshen Dripping Pills combined with Valsartan has a more significant effect on blood pressure control in elderly patients with essential hypertension and is helpful for the recovery of vascular endothelial function.It is worthy of further clinical investigation.
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| [1] |
肖金翠，刘大男，李治菁.中老年原发性高血压伴冠心病及微量蛋白尿与动脉弹性的相关性[J].中华老年心脑血管病杂志，2018，20（5）：483-486.
|
| [2] |
范振兴，孙希鹏，王艳玲，等.降压联合调脂治疗对轻度原发性高血压患者血管内皮功能的影响[J].中国心血管病研究，2019，17（5）：464-469.
|
| [3] |
李磊，周跟东，李胜，等.不同剂量阿托伐他汀联合缬沙坦对高血压患者血压变异性及昼夜节律的影响[J].中国医师进修杂志，2020，43（6）：540-544.
|
| [4] |
王伟英，任娜，刘丽.降压治疗对原发性高血压患者血清不规则趋化因子水平和血管内皮功能的影响[J].心脑血管病防治，2020，20（4）：86-87，93.
|
| [5] |
包恩泽，李贵华，皮林，等.联合降压药物方案治疗老年原发性高血压疗效及作用机制研究[J].临床军医杂志，2019，47（3）：231-233.
|
| [6] |
黄伟明，罗永红，莫修哲，等.复方丹参滴丸治疗血瘀型老年性高血压病临床疗效观察[J].辽宁中医药大学学报，2019，21（7）：22-25.
|
| [7] |
刘力生.中国高血压防治指南（2010）[J].中华高血压杂志，2011，8（12）：701-743.
|
| [8] |
郭浩，高波，李江，等.卡维地洛联合缬沙坦氢氯噻嗪治疗顽固性高血压的临床研究[J].现代药物与临床，2019，20（9）：2617-2621.
|
| [9] |
卿山林，骆强，任波，等.高剂量缬沙坦对老年糖尿病肾病伴高血压患者血压及心肾功能的影响[J].成都医学院学报，2020，15（2）：117-120.
|
| [10] |
杨艳，乔克，胡来明，等.缬沙坦联合镇肝熄风汤对老年非杓型高血压患者血小板活化及纤溶活性的影响[J].现代中西医结合杂志，2020，29（14）：1546-1549.
|
| [11] |
郎立中.复方丹参滴丸联合苯磺酸氨氯地平叶酸片对H型高血压患者血液指标的影响[J].世界最新医学信息文摘（电子版），2019，19（37）：203-204.
|
| [12] |
白飞鹏.复方丹参滴丸联合坎地沙坦治疗高血压左心室肥厚效果观察[J].临床合理用药杂志，2019，12（7）：51-52.
|
| [13] |
宋国丰.复方丹参滴丸辅助治疗老年单纯收缩期高血压的效果观察[J].中国保健营养，2019，13（15）：251.
|
| [14] |
秦英荣，陈永锐，徐春玉.复方丹参滴丸联合缬沙坦片治疗原发性高血压的疗效[J].内蒙古中医药，2020，39（5）：54-55.
|
| [15] |
方永有，刘莉，魏晓，等.复方丹参滴丸对中老年男性原发性高血压患者的影响[J].检验医学与临床，2018，15（3）：347-349，352.
|
|
|
|
