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| Analysis of Acinetobacter baumannii infection and drug resistance |
| YANG Jin-ping Z HANG Xian-ming ZHENG Ding-rong |
| Department of Blood Transfusion,Central Hospital of Bao′an District in Shenzhen City,Guangdong Province,Shenzhen 518102,China |
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Abstract Objective To explore and analyze the clinical specimens,the drug resistance and resistance genes detected genotype distribution of Acinetobacter baumannii(Ab).Methods A total of 234 Ab strains isolated from various specimens of hospitalized patients in Central Hospital of Bao′an District in Shenzhen City from January 2018 to May 2020 were analyzed.The susceptibility of 18 antimicrobial agents was detected by Kirby-Bauer method(K-B method),and then the distribution of the encoding gene of extended spectrum β-lactamases(ESBLs)was detected by polymerase chain reaction(PCR).Results The main departments of Ab were ICU,respiratory medicine,nephrology and neurosurgery.Specimen types were sputum,pus and ascites.Ab was widely resistant to commonly used clinical antibiotics,among them,Ampicillin,Cefotetan and Aztreonam had the higher drug resistance rates.The resistance rate of Amikacin and Polymyxin B were relatively low.The drug resistance genes were mainly OXA-51,OXA-23,TEM,CTX-M1,CTX-M9,SHV and ADC,OXA-51 and OXA-23 were higher,both exceeding 75%.The proportion of strains both carrying OXA-23 and OXA-51 was the highest,which was 64.96%.Conclusion Ab in Central Hospital of Bao′an District in Shenzhen City was mainly distributed in the ICU and respiratory medicine,with sputum,pus and ascites as the main specimen types.Ab is widely resistant to a variety of antibacterial drugs and most of the strains carry resistance genes in our hospital.The ratio of strains carrying more than two genes is relatively high.The monitoring of drug resistant Ab should be strengthened in clinical practice,rational drug use should be strengthened,and the generation of drug-resistant strains should be controlled and restrained.
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