膀胱内灌注无菌透明质酸钠溶液治疗膀胱过度活动症的临床效果

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Abstract Objective To explore the clinical effectiveness and safety of intravesical infusion of Sterile Sodium Hyaluronate Solution in the treatment of overactive bladder(OAB).Methods From June 2016 to December 2019,150 patients with OAB diagnosed in the Outpatient Department of Pingxiang People′s Hospital were selected and randomly divided into the Sterile Sodium Hyaluronate group and the Solinacine group according to random number table method,with 75 cases in each group.The Sterile Sodium Hyaluronate group was intravesically perfused with Sodium Hyaluronate,and the Solinacine group was orally administered with Solinacin Succinate.Both groups were treated for 6 months.The overactive bladder symptom score (OABSS),urodynamic parameters and adverse reactions were compared between the two groups before and after treatment.Results After 6 months of treatment,The total score of OABSS and the scores of diurnal urination,nocturnal urination,urgent urination and urgent urinary incontinence in the Sterile Sodium Hyaluronate group were lower than those in the Solinacine group,the differences were statistically significant(P＜0.05).The volume at first desire and maximum cystometric capacity of the Sterile Sodium Hyaluronate group were higher than those of the Solinacine group,and the maximum urinary flow rate of the Sterile Sodium Hyaluronate group was lower than that of the Solinacine group,the differences were statistically significant(P＜0.05).There were no serious adverse reactions between the two groups.There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Sodium hyaluronate bladder perfusion is safe and effective in the treatment of OAB,which can effectively relieve OAB symptoms and improve bladder function.It is an optional treatment.

Key words： Sterile Sodium Hyaluronate Intravesical perfusion Overactive bladder Solinasine

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	KANG Xi
	ZHANG Ting
	WANG Jun
	HU Hai-bing
	XIE Zhen-lian

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KANG Xi,ZHANG Ting,WANG Jun, et al. Clinical effect of intravesical infusion of Sterile Sodium Hyaluronate Solution in the treatment of overactive bladder[J]. 中国当代医药, 2021, 28(31): 107-110.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I31/107

[1]	Chuang YC，Liu SP，Lee KS，et al.Prevalence of overactive bladder in China，Taiwan and South Korea：results from a cross-sectional，population-based study[J].Low Urin Tract Symptoms，2019，11（1）：48-55.
[2]	赵紫楠，李婷，李超，等.索利那新治疗膀胱过度活动症的快速卫生技术评估[J].中国药业，2019，28（19）：1-5.
[3]	Wang J，Zhou Z，Cui Y，et al.Meta-analysis of the efficacy and safety of mirabegron and solifenacin monotherapy for overactive bladder[J].Neurourol Urodyn，2019，38（1）：22-30.
[4]	倪永梁，周强，史本康，等.透明质酸及其钠盐形式在膀胱功能和疾病中的研究进展[J].现代泌尿外科杂志，2017，22（9）：722-725.
[5]	王黎，但超，陈从波，等.臭氧水膀胱腔内灌注治疗女性膀胱过度活动症疗效评价[J].现代生物医学进展，2019，19（1）：125-128.
[6]	Madersbacher H，van Ophoven A，van Kerrebroeck PE.GAG layer replenishment therapy for chronic forms of cystitis with intravesicalglycosaminoglycans——areview[J].NeurourolUrodyn，2013，32（1）：9-18.
[7]	金锡御，宋波，杨勇，等.膀胱过度活动症临床指导原则[J].中华泌尿外科杂志，2002，33（5）：311-313.
[8]	许克新，汪磊，王晓峰，等.膀胱过度活动症症状评分表对中国OAB患者结果评估的重复信度及与其他症状评分工具间相关性的研究[J].中国泌尿外科杂志，2010，31（11）：727-731.
[9]	Robinson D，Cardozo L.Managing overactive bladder[J].Climacteric，2019，22（3）：250-256.
[10]	孔令军，赵佳龙.索利那新对膀胱过度活动症病人逼尿肌功能及预后的影响[J].临床外科杂志，2019，27（9）：798-800.
[11]	Wang HT，Xia M.Comparisons of therapeutic efficacy and safety of Solifenacin versus tolterodine in patients with overactive bladder：a Meta-analysis[J].Urol Int，2019，103（2）：187-194.
[12]	李雯，陈跃来.黏膜各层结构中信号通路与受体在膀胱过度活动症中的作用[J].中国组织工程研究，2021，26（26）：4230-4235.
[13]	李杰荣，刘国庆，唐华健，等.女性膀胱过度活动症患者临床病理学研究[J].中国当代医药，2010，17（22）：107-108.
[14]	李碧怡，李宇麟，彭嘉健，等.伤科黄水膀胱灌注治疗女性膀胱过度活动症的临床研究[J].中医药学报，2020，48（10）：43-47.
[15]	高宏亮，夏志军.膀胱过度活动症及间质性膀胱炎膀胱灌注治疗的研究进展[J].临床与病理杂志，2017，37（8）：1721-1726.
[16]	Madersbacher H，van Ophoven A，van Kerrebroeck PE.GAG layer replenishment therapy for chronic forms of cystitis with intravesical glycosaminoglycans——a review[J].Neurourol Urodyn，2013，32（1）：9-18.
[17]	秦美英，高宏亮，夏志军.索利那新联合透明质酸钠膀胱灌注对重度女性膀胱过度活动症的治疗效果[J].中国妇产科临床杂志，2019，20（2）：108-111.
[18]	Batura D，Warden R，HashemzehiT，etal.Intravesical sodium hyaluronate reduces severity，frequency and improves quality of life in recurrent UTI[J].Int Urol Nephrol，2020，52（2）：219-224.